Recombinant KLRK1 anticorps

N° du produit ABIN7543178

Cet anticorps Rat Monoclonal détecte spécifiquement KLRK1 dans FACS, BP et Neut. Il présente une réactivité avec des échantillons de Souris.

Aperçu rapide pour Recombinant KLRK1 anticorps (ABIN7543178)

Antigène: KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))

Type d'anticorp: Recombinant Antibody

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp KLRK1 est non-conjugé

Application: Flow Cytometry (FACS), Blocking Peptide (BP), Neutralization (Neut)

Clone: CX-5

Détail du produit anti-KLRK1 anticorps

Fonction: Anti-NKG2D [CX-5], Rat IgG1, lambda

Specificité: This antibody recognizes mouse NKG2D, a lectin-like molecule expressed on both human and mouse NK cells. Mouse NKG2D binds to retinoic acid-inducible RAE-1 alpha, beta, gamma, delta, epsilon and the minor histocompatibility molecule H60 and has the ability to costimulate multiple NK activation receptors, through the DAP12/DAP10 adaptor molecules. NKG2D is expressed by all spleen and liver NK cells, NK1.1 thymocytes, in vitro activated LAK cells, and a subset of splenic NKT cells.

Attributs du produit:

Original Species of Ab: Rat

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogène: The original rat IgG1 version of this antibody was raised by immunizing rats against mouse KLRK1.

Isotype: IgG1 lambda

Information d'application

Indications d'application: It has been shown that CX5 is a non-depleting antibody, which blocks binding of NKG2D to its ligands and mediates internalization of the receptor. This antibody has been widely used to block NKG2D (Wang et al., 2018, pmid: 29447423, Yang et al., 2017, pmid: 28455530) as well as to detect NKG2D-posotive cells via flow cytometry (Hosomi et al., 2017, pmid: 28747426).

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur KLRK1

Antigène: KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))

Autre désignation: NKG2D

Sujet: CD314, KLRK1, NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D-activating NK receptor, CX5

UniProt: O54709

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process