Recombinant CD7 anticorps

N° du produit ABIN7543249

Cet anticorps anti-CD7 est un anticorps Souris Monoclonal détectant CD7 dans FACS. Adapté pour Humain.

Aperçu rapide pour Recombinant CD7 anticorps (ABIN7543249)

Antigène: CD7

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD7 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: 3A1f

Détail du produit anti-CD7 anticorps

Fonction: Anti-CD7 [3A1f], Mouse IgG1, kappa

Specificité: This antibody binds human CD7. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. CD7 is useful in the identification of precursor T cells as well as an important marker for the identification of leukemic T cells.

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Isotype: IgG1 kappa

Information d'application

Indications d'application: The binding affinity of the scFv version of this antibody was determined using surface plasmon resonance. The affinity of the scFv antibody for human CD7 was found to be 1.8 nM. This the scFv version of this antibody was also used in the generation of single-chain Fv (scFv) immunotoxins specific for the T cell-associated antigen CD7 as a novel therapeutic agent for treatment of human T cell malignancies (PMID: 9120282). This antibody was also used in the generation of a therapeutic fusion protein scFvCD7:sTRAIL, designed to induce target antigen-restricted apoptosis in human T-cell tumors. The binding of the fusion protein to CD7 was tested with flow cytometry (PMID: 15833872).

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur CD7

Antigène: CD7

Autre désignation: CD7

Sujet: GP40, TP41, T-cell antigen CD7, T-cell leukemia antigen, T-cell surface antigen Leu-9, 3aIf

UniProt: P09564

Pathways: Cell-Cell Junction Organization