Recombinant PD-1 anticorps (AA 32-160)

N° du produit ABIN7543294

Cet anticorps anti-PD-1 est un anticorps Lapin Chimeric détectant PD-1 dans WB, IHC et ELISA. Adapté pour Humain.

Aperçu rapide pour Recombinant PD-1 anticorps (AA 32-160) (ABIN7543294)

Antigène: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp PD-1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 11F5C5

Détail du produit anti-PD-1 anticorps

Épitope: AA 32-160

Fonction: Anti-PD-1 [11F5C5], Rabbit IgG, kappa

Specificité: This antibody binds the extracellular domain of the human PD-1. PD-1 is an immunosuppressive receptor having a molecular weight of 50 to 55 kD, a type 1 transmembrane glycoprotein belonging to immunoglobulin CD28 / CTLA-4 family members. It is an inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. It delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2.

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogène: The original antibody was generated by immunizing BALB/c mice with recombinant human PD-1 protein comprising amino acids 32-160.

Isotype: IgG kappa

Information d'application

Indications d'application: This antibody is highly similar to the commercially available anti-PD-1 antibody NAT105. The binding specificity of this antibody towards human PD-1 was determined using ELISA. The original IgG2a antibody binds human PD_1 with an affinity constant of 7.13X10^9 M^(-1). This antibody is capable of detecting human PD-1 in a western blot assay. This antibody was used in the immunohistochemical staining of samples of T cell lymphomas and B cell lymphomas (CN109293775).

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format for improved compatibility with existing reagents assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur PD-1

Antigène: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Autre désignation: PD-1

Sujet: CD279, PD1, PD 1, hPD-1, PDCD1, Programmed cell death protein 1, Programmed cell death 1, Protein PD-1, CGMCC NO.16209, NAT105

UniProt: Q15116

Pathways: Cancer Immune Checkpoints