Recombinant KRT8 anticorps (AA 340-365)

N° du produit ABIN7543313

Cet anticorps Souris Monoclonal détecte spécifiquement KRT8 dans WB, IHC, ELISA et IP. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant KRT8 anticorps (AA 340-365) (ABIN7543313)

Antigène: KRT8 (Keratin 8 (KRT8))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KRT8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Clone: TS1

Détail du produit anti-KRT8 anticorps

Épitope: AA 340-365

Fonction: Anti-Cytokeratin 8 [TS1], Mouse IgG1, kappa

Specificité:

This antibody binds a discontinuous epitope on helical 2B domain of the human cytokeratin 8 between amino acid residues 340-365 (QRGELAIKDANAKLSELEAALQRAKQ). Cytokeratins are intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. Together with KRT19, cytokeratin 8 helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Cytokeratin 8 is a serological tumor marker

Application Notes original Clone: This antibody has specific reactivity for human cytokeratin 8. The binding characterization and epitope mapping of this antibody was done using ELISA (PMID: 9486565, 9892182). This antibody was also capable of immunoprecipitating human cytokeratin 8 from a sample. This antibody can be used in the identification of cytokeratin 8 in a western blot assay. This antibody was also used in the immunohistochemical staining of frozen sections of normal human adult tissues like skin, esophagus and liver (PMID: 2479674). This antibody is capable of binding cytokeratin 8 expressed on carcinomas in vivo. This antibody was used for the radio immunolocalization of cytokeratin 8 and radioimmunotherapy (PMID: 9892182, 7493362, 9406704).

Purification: Protein A affinity purified

Immunogène: The original antibody was generated by immunizing BALB/c mice with purified human gastrointestinal tumor derived cytokeratin.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

OriginalSpeciesName: Mouse

OriginalFormat: IgG1

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur KRT8

Antigène: KRT8 (Keratin 8 (KRT8))

Autre désignation: Cytokeratin 8

Sujet: CK8, CK-8, CK 8, KRT8, CYK8, Keratin type II cytoskeletal 8, Cytokeratin-8, Type-II keratin Kb8, TS 1, Mab 202

UniProt: P05787