Recombinant K-RAS anticorps (Glu12Asp Mutant)

N° du produit ABIN7543442

Cet anticorps Souris Monoclonal détecte spécifiquement K-RAS dans ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour Recombinant K-RAS anticorps (Glu12Asp Mutant) (ABIN7543442)

Antigène: K-RAS (KRAS) (GTPase Kras (KRAS))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp K-RAS est non-conjugé

Application: ELISA

Clone: D113

Détail du produit anti-K-RAS anticorps

Épitope: Glu12Asp Mutant

Fonction: Anti-KRAS G12D mutant [D113], Mouse IgG1, kappa

Specificité: This antibody binds the G12D mutant form of human KRAS protein. This ras protein binds GDP/GTP and possess intrinsic GTPase activity, that results in conversion of nucleotide guanosine triphosphate (GTP) into guanosine diphosphate (GDP). This protein plays an important role in many signal transduction pathways and regulation of cell proliferation. Somatic KRAS mutations are highly observed in leukemias, colorectal cancer, pancreatic cancer and lung cancer. KRAS mutation is G12D which is estimated to be present in up to 37 % pancreatic cancers and over 12 % of colorectal cancers.

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogène: The original antibody was generated by immunizing mice with a synthetic dodecapeptide 'KLVVVGADGVGK'.

Isotype: IgG1 kappa

Information d'application

Indications d'application: The binding reactivity and epitope characterization of this antibody towards human KRAS G12D mutant was determined using ELISA (PMID: 9440050). This antibody can bind both the peptide 'KLVVVGADGVGK' conjugated BSA as well as KRAS G12D mutant in an ELISA.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur K-RAS

Antigène: K-RAS (KRAS) (GTPase Kras (KRAS))

Autre désignation: KRAS

Sujet: K-Ras, GTPase Kras, KRAS2, RASK2, K-Ras 2, Ki-Ras, c-K-ras, c-Ki-ras, ras p21 protein, p21 ras, D113-2-1

UniProt: P01116-2