Recombinant Ferritin anticorps

N° du produit ABIN7543451

Cet anticorps Lapin Chimeric détecte spécifiquement Ferritin dans IP. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant Ferritin anticorps (ABIN7543451)

Antigène: Ferritin (FE)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp Ferritin est non-conjugé

Application: Immunoprecipitation (IP)

Clone: AMB8LK

Détail du produit anti-Ferritin anticorps

Fonction: Anti-Ferritin [AMB8LK], Rabbit IgG, kappa

Specificité:

This antibody binds human ferritin. This protein catalyzes the oxidation of ferrous iron(II) to ferric iron(III) and stores iron in a soluble, non-toxic, readily available form. Ferritin is important for iron homeostasis.

Application Notes original Clone: This antibody was capable of immunoprecipitating ferritin (PMID: 6817879). The original antibody binds human ferritin with a binding affinity of Kd= 5.1nM (EP2193147). The thiolated version of this antibody was conjugated to maleimide-activated polylactide nanoparticles (NPs) to generate immunonanoparticles, which may carry drugs to desired overexpressing antigen cells potentially leading to improved drug therapy and reduced systemic adverse effects (PMID: 19835957). Preclinical studies showed that the immunoconjugate with 90Y has 98 % stability over 7 days. A very good pancreatic adenocarcinoma tumor targeting was observed especially with the Bz-DTPA-AMB8LK (PMID: 17383579)

Attributs du produit: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Purification: Protein A affinity purified

Immunogène: The original antibody was generated by immunizing female Balb/c mice with ferritin extracted from human spleen cells.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

OriginalSpeciesName: Mouse

OriginalFormat: IgG1

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur Ferritin

Antigène: Ferritin (FE)

Autre désignation: Ferritin

Sujet: FTMT, FTL, FTH1, Ferritin mitochondrial, B8

UniProt: Q8N4E7

Pathways: Transition Metal Ion Homeostasis