Recombinant TCR gamma/delta anticorps

N° du produit ABIN7543458

L’anticorps anti-TCR gamma/delta Monoclonal Souris est utilisé pour la détection de TCR gamma/delta dans des échantillons de Humain. Il a été validé pour FACS et Func.

Aperçu rapide pour Recombinant TCR gamma/delta anticorps (ABIN7543458)

Antigène: TCR gamma/delta (T-Cell Receptor gamma/delta (TCR gamma/delta))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TCR gamma/delta est non-conjugé

Application: Flow Cytometry (FACS), Functional Studies (Func)

Clone: G5-4

Détail du produit anti-TCR gamma/delta anticorps

Fonction: Anti-Gamma Delta TCR [G5-4], Mouse IgG2a, kappa

Specificité: This antibody is specific for the human TCR delta and gamma chains. The T-cell receptor (TCR) is a molecule found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. On activation through antigen presenting cells (APCs), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. TCR part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response.

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogène: The original antibody was generated by immunizing BALB/c mice with recombinant gamma9delta2 (OT3)-Fc fusion protein as an immunogen.

Isotype: IgG2a kappa

Information d'application

Indications d'application: The binding of this antibody to γδ T cells was determined using flow cytometry. This antibody can compete with commercially available anti-γδ TCR antibody IMMU510 for binding to gamma-delta T cells. It is proposed that, since there is some competition between the two antibodies, G5-4 binds a similar or identical epitope to IMMU510. In an in vitro proliferation assay, this antibody was reported to positively stimulate the proliferation of γδT cells. The scFv version of this antibody was also reported to stimulate the secretion of cytokines like IFN-γ and TGF-α. G5-4ScFv-amplified γδT cells can effectively kill daudi cells, and the killing efficiency is greater than 85 % when the effect-to-target ratio is 5:1 (CN103130894).

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur TCR gamma/delta

Antigène: TCR gamma/delta (T-Cell Receptor gamma/delta (TCR gamma/delta))

Autre désignation: Gamma Delta TCR

Sujet: TCR γδ, γδ TCR, TCR GD, GD TCR, TCRg/d, T-cell surface glycoprotein CD3 delta chain, CD3D, T3D, T-cell receptor T3 delta chain, T-cell surface glycoprotein CD3 gamma chain, CD3G, T-cell receptor T3 gamma chain, CD3g, T3G

UniProt: P04234, P09693