Recombinant CRHR2 anticorps

N° du produit ABIN7566415

Cet anticorps Human Monoclonal détecte spécifiquement CRHR2 dans WB, ELISA, IHC, IF et Func. Il présente une réactivité envers Aspergillus fumigatus.

Aperçu rapide pour Recombinant CRHR2 anticorps (ABIN7566415)

Antigène: CRHR2 (Corticotropin Releasing Hormone Receptor 2 (CRHR2))

Type d'anticorp: Recombinant Antibody

Reactivité: Aspergillus fumigatus

Hôte: Human

Clonalité: Monoclonal

Conjugué: Cet anticorp CRHR2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Functional Studies (Func)

Clone: MS112-IIA1

Détail du produit anti-CRHR2 anticorps

Fonction: anti-Crf2 (Aspergillus fumigatus), mAb (rec.) (MS112-IIA1)

Attributs du produit:

Recombinant Antibody. Recognizes Crf2 from Aspergillus fumigatus. Possible cross-reactivity with Crf1, Crf2 and Asp f9 [Reference 2]. Applications: ELISA, FUNC, IHC, WB, IF. Clone: MS112-IIA1. Isotype: Human IgG1. Formulation: Liquid. In PBS. Aspergillus fumigatus is a common airborne fungal pathogen for humans. It frequently causes an invasive aspergillosis (IA) in immunocompromised patients with poor prognosis. Potent antifungal drugs are very expensive and cause serious adverse effects. Their correct application requires an early and specific diagnosis of IA. Encoded by CRF1 gene, the Crf protein family contains three protein variants: Crf2 protein, amino acids (333 aa) long, Asp f9 protein (292 aa), first identified as an allergen using serum from Aspergillus-allergic patients and Crf1 (395 aa, also named Crh5). The glycosyol hydrolase/glycosidase Crf2 catalyzes the hydrolysis of glycosidic bonds in complex sugars and is located in the cell wall of the growing hyphae. Crf2 may be involved in the remodeling of the cell wall as well, and therefore in the growth and the virulence of the fungus.

Aspergillus fumigatus is a common airborne fungal pathogen for humans. It frequently causes an invasive aspergillosis (IA) in immunocompromised patients with poor prognosis. Potent antifungal drugs are very expensive and cause serious adverse effects. Their correct application requires an early and specific diagnosis of IA. Encoded by CRF1 gene, the Crf protein family contains three protein variants: Crf2 protein, amino acids (333 aa) long, Asp f9 protein (292 aa), first identified as an allergen using serum from Aspergillus-allergic patients and Crf1 (395 aa, also named Crh5). The glycosyol hydrolase/glycosidase Crf2 catalyzes the hydrolysis of glycosidic bonds in complex sugars and is located in the cell wall of the growing hyphae. Crf2 may be involved in the remodeling of the cell wall as well, and therefore in the growth and the virulence of the fungus.

Purification: Puified

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant Crf2 (Aspergillus fumigatus) containing a C-terminal His-tag.

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS.

Conseil sur la manipulation: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.Please handle under sterile conditions to avoid contamination.

Stock: 4 °C,-20 °C

Stockage commentaire:

Stable for at least 1 year after receipt when stored at -20°C.

Stable for at least 1 week when stored at +4°C.

Détails sur CRHR2

Antigène: CRHR2 (Corticotropin Releasing Hormone Receptor 2 (CRHR2))

Autre désignation: Crf2

UniProt: Q4WI46

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Feeding Behaviour