Fibronectin anticorps

N° du produit ABIN7566419

L’anticorps Souris Monoclonal anti-Fibronectin a été validé pour WB, IHC, ELISA, ICC et Func. Il convient pour détecter Fibronectin dans des échantillons de Humain, Rat, Souris, Porc, Boeuf (Vache), Poulet, Chien et Singe.

Aperçu rapide pour Fibronectin anticorps (ABIN7566419)

Antigène: Fibronectin

Reactivité: Humain, Rat, Souris, Porc, Boeuf (Vache), Poulet, Chien, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Fibronectin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Functional Studies (Func)

Clone: IST-9

Détail du produit anti-Fibronectin anticorps

Fonction: anti-Fibronectin (EDA), mAb (blocking) (IST-9) (preservative free)

Attributs du produit:

Monoclonal Antibody. Isotype: Mouse IgG1.Immunogen: Recombinant Extra Domain A (EDA) region of human cellular fibronectin.. Application: ELISA, FUNC (Blocking), ICC, IHC, WB. Sterile liquid. In PBS. Recombinant Extra Domain A (EDA) region of human cellular fibronectin. Fibronectin is a major component of the extracellular matrix that binds to integrins, cell surfaces and various compounds including collagen, fibrin, heparin, DNA and actin. It occurs in two main forms: plasma and cellular fibronectin. EDA (Extra Domain A)-containing cellular fibronectin (EDA-FN) plays a major role in cell adhesion, growth, migration and differentiation and it is important for processes such as wound healing and embryonic development. It is associated with fibroblast differentiation by increasing alpha-SMA expression, collagen deposition, cell contractility and focal adhesion kinase (FAK) activation. EDA-FN promotes cell spread by interacting with the integrins alpha5-beta1, alpha4-beta1 and alpha9-beta1 and has been shown to promote angiogenesis, lymphangiogenesis and metastasis of colorectal tumors. In transformed or tumor-derived cells the EDA segment is about 10-times higher than in fibronectin from normal fibroblasts and it may therefore be a significant marker for malignancy.

Fibronectin is a major component of the extracellular matrix that binds to integrins, cell surfaces and various compounds including collagen, fibrin, heparin, DNA and actin. It occurs in two main forms: plasma and cellular fibronectin. EDA (Extra Domain A)-containing cellular fibronectin (EDA-FN) plays a major role in cell adhesion, growth, migration and differentiation and it is important for processes such as wound healing and embryonic development. It is associated with fibroblast differentiation by increasing alpha-SMA expression, collagen deposition, cell contractility and focal adhesion kinase (FAK) activation. EDA-FN promotes cell spread by interacting with the integrins alpha5-beta1, alpha4-beta1 and alpha9-beta1 and has been shown to promote angiogenesis, lymphangiogenesis and metastasis of colorectal tumors. In transformed or tumor-derived cells the EDA segment is about 10-times higher than in fibronectin from normal fibroblasts and it may therefore be a significant marker for malignancy.

Purification: Puified

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant Extra Domain A (EDA) region of human cellular fibronectin.

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Sterile liquid. In PBS.

Agent conservateur: Without preservative

Conseil sur la manipulation: After opening, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

+4°C

Stable for at least 1 year after receipt when stored at -20°C.

Détails sur Fibronectin

Antigène: Fibronectin