Periostin anticorps

N° du produit ABIN7566439

Cet anticorps Souris Monoclonal détecte spécifiquement Periostin dans ICC et Func. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour Periostin anticorps (ABIN7566439)

Antigène: Periostin (POSTN)

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Periostin est non-conjugé

Application: Immunocytochemistry (ICC), Functional Studies (Func)

Clone: OC-20

Détail du produit anti-Periostin anticorps

Fonction: anti-Periostin, mAb (blocking) (OC-20) (preservative free)

Attributs du produit:

Monoclonal Antibody. Isotype: Mouse IgMkappa.Immunogen: Recombinant fragments of human periostin.. Application: FUNC (Blocking), ICC. Liquid. In PBS. Recombinant fragments of human periostin. Periostin is a 90- kDa matricellular protein that consists of a typical signal sequence, followed by a cysteine-rich region, an EMI domain (protein-protein interactions), four tandem fasciclin-like domains that are responsible for integrin binding, and a C-terminal region. Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and in osteoblast recruitment, attachment and spreading. Periostin is also involved in many fundamental biological processes such as cell proliferation, cell invasion and angiogenesis. Periostin expression is increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2). Changes in periostin expression are commonly detected in various cancers and pre-cancerous conditions, and periostin may be involved in regulating cancer cell activities that contribute to tumorigenesis, cancer progression and metastasis. Periostin has shown to be involved in many aspects of allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype and increased expression of inflammatory mediators. It is evaluated as a biomarker for bronchial asthma and airway inflammation.

Periostin is a 90- kDa matricellular protein that consists of a typical signal sequence, followed by a cysteine-rich region, an EMI domain (protein-protein interactions), four tandem fasciclin-like domains that are responsible for integrin binding, and a C-terminal region. Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and in osteoblast recruitment, attachment and spreading. Periostin is also involved in many fundamental biological processes such as cell proliferation, cell invasion and angiogenesis. Periostin expression is increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2). Changes in periostin expression are commonly detected in various cancers and pre-cancerous conditions, and periostin may be involved in regulating cancer cell activities that contribute to tumorigenesis, cancer progression and metastasis. Periostin has shown to be involved in many aspects of allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype and increased expression of inflammatory mediators. It is evaluated as a biomarker for bronchial asthma and airway inflammation.

Purification: Puified

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant fragments of human periostin.

Isotype: IgM kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS.

Agent conservateur: Without preservative

Conseil sur la manipulation: After opening, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

+4°C

Stable for at least 1 year after receipt when stored at -20°C.

Détails sur Periostin

Antigène: Periostin (POSTN)

Autre désignation: Periostin