TNFSF13 anticorps

N° du produit ABIN7566471

Cet anticorps anti-TNFSF13 est un anticorps Souris Monoclonal détectant TNFSF13 dans ELISA et IP. Adapté pour Humain et Souris.

Aperçu rapide pour TNFSF13 anticorps (ABIN7566471)

Antigène: TNFSF13 (Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TNFSF13 est non-conjugé

Application: ELISA, Immunoprecipitation (IP)

Clone: Heaty-1

Détail du produit anti-TNFSF13 anticorps

Fonction: anti-APRIL, mAb (Heaty-1)

Attributs du produit:

Monoclonal Antibody. Recognizes mouse and human recombinant and endogenous APRIL. Isotype: Mouse IgG2b. Immunogen: Recombinant mouse APRIL. Applications: ELISA, IP. Liquid. In PBS containing 0.02 % Proclin 300. APRIL is a secreted cytokine, belonging to the TNF superfamily that binds to transmembrane activator and CAML interactor (TACI), B cell maturation antigen (BCMA) and can interact with carbohydrate side chains of heparan sulfate proteoglycans (HSPG) that may trigger cross-linking. APRIL maintains B cell homeostasis by acting at a later stage, modulating the function and survival of antigen-experienced B cells. APRIL (as well as BAFF) stimulates class-switch recombination (CSR), hence contributes to shaping humoral effector mechanisms. With regards to humoral memory, APRIL is involved in the establishment and survival of the long-lived plasma cell (LLPC) pool in the bone marrow (BM). Recently, APRIL has been shown to confer atheroprotection via binding to heparan sulfate (HS) chains of heparan-sulfate proteoglycan 2 (HSPG2), which limits LDL retention,macrophage accumulation and necrotic core formation.

APRIL is a secreted cytokine, belonging to the TNF superfamily that binds to transmembrane activator and CAML interactor (TACI), B cell maturation antigen (BCMA) and can interact with carbohydrate side chains of heparan sulfate proteoglycans (HSPG) that may trigger cross-linking. APRIL maintains B cell homeostasis by acting at a later stage, modulating the function and survival of antigen-experienced B cells. APRIL (as well as BAFF) stimulates class-switch recombination (CSR), hence contributes to shaping humoral effector mechanisms. With regards to humoral memory, APRIL is involved in the establishment and survival of the long-lived plasma cell (LLPC) pool in the bone marrow (BM). Recently, APRIL has been shown to confer atheroprotection via binding to heparan sulfate (HS) chains of heparan-sulfate proteoglycan 2 (HSPG2), which limits LDL retention,macrophage accumulation and necrotic core formation.

Purification: Puified

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant mouse APRIL.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS containing 0.02 % Proclin 300.

Conseil sur la manipulation: After opening, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

+4°C

Stable for at least 1 year after receipt when stored at -20°C.

Détails sur TNFSF13

Antigène: TNFSF13 (Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13))

Autre désignation: APRIL

UniProt: Q9D777

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response