CCR6 anticorps (Elab Fluor®700)

N° du produit ABIN7566895

Cet anticorps Souris Monoclonal détecte spécifiquement CCR6 dans FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour CCR6 anticorps (Elab Fluor®700) (ABIN7566895)

Antigène: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CCR6 est conjugé à/à la Elab Fluor®700

Application: Flow Cytometry (FACS)

Clone: G034E3

Détail du produit anti-CCR6 anticorps (Elab Fluor®700)

Fonction: Elab Fluor®700 Anti-Human CD196/CCR6 Antibody[G034E3]

Isotype: IgG1, kappa

Information d'application

Indications d'application: Each lot of this antibody is quality control tested by flow cytometric analysis. Applications vary, the appropriate dilutions must be determined for individual use.

Commentaires:

Matching Isotype Control: E-AB-F09812M1

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09 % stabilizer and 1 % protein protectant.

Stock: 4 °C

Stockage commentaire: This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Date de péremption: 12 months

Détails sur CCR6

Antigène: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Autre désignation: CD196/CCR6

Sujet: CMKBR6, GPR29, STRL22,CKRL3,GPRCY4,CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

ID gène: 1235

UniProt: P51684

Pathways: cAMP Metabolic Process