FLRT3 anticorps (Extracellular, N-Term)

N° du produit ABIN7581871

Cet anticorps Lapin Polyclonal détecte spécifiquement FLRT3 dans WB, IHC, FACS et LCI. Il présente une réactivité avec des échantillons de Rat.

Aperçu rapide pour FLRT3 anticorps (Extracellular, N-Term) (ABIN7581871)

Antigène: FLRT3 (Fibronectin Leucine Rich Transmembrane Protein 3 (FLRT3))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FLRT3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-FLRT3 anticorps

Épitope: AA 387-401, Extracellular, N-Term

Fonction: A Rabbit Polyclonal antibody to FLRT3 (extracellular)

Séquence: (C)KQPDIKNPKL TKDQR

Homologie: Mouse - 14 out of 15 amino acids identical,Human - 13 out of 15 amino acids identical

Attributs du produit: Anti-FLRT3 (extracellular) Antibody (ABIN7581871) is a highly specific antibody directed against an extracellular epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize FLRT3 from mouse, rat and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)KQPDIKNPKLTKDQR, corresponding to amino acid residues 387 - 401 of rat FLRT3 

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur FLRT3

Antigène: FLRT3 (Fibronectin Leucine Rich Transmembrane Protein 3 (FLRT3))

Autre désignation: FLRT3 

Sujet:

Synonyms: Fibronectin Leucine Rich Transmembrane Protein 3, Leucine-rich repeat transmembrane protein FLRT3

Description: The leucine-rich repeat (LRR) superfamily is a diverse protein family that consist of leucine-rich domains (LRR domains). The LRR domain is known to regulate protein-protein interaction or cell adhesion. A Large portion of LRR proteins mediate the differentiation and development of nervous tissues1.The fibronectin leucine-rich transmembrane 3 (FLRT3) protein play an important function during excitatory neuron development including neuron migration, axon guidance, or synapse formation2. FLRT3 gene is encoding single pass transmembrane domain with one extracellular LRR domain and a juxtamembrane fibronectin type 3 (FNIII) module. It was found to be expressed in kidney, brain, pancreases, skeletal muscle, lungs, liver placenta and heart3.FLRT3 display a unique multifunctional property acting as chemorepellent by binding to the Netrin receptor Unc5D and regulating radial migration of subventricular progenitors. In addition, it acts as homophilic adhesion molecule regulating the tangential dispersion of migrating neuron progenitors in the developing cortex4. FLRT3 knock out in mice leads to a variety of malformations, like disorganized basement membrane, failure of embryonic turning and ventral body closure, cardiac bifida and asymmetric development of headfolds5.

ID gène: 366205

UniProt: B1H234