KCNN4 anticorps (Extracellular) (PE)

N° du produit ABIN7581911

L’anticorps anti-KCNN4 Monoclonal Souris est utilisé pour la détection de KCNN4 dans des échantillons de Humain. Il a été validé pour WB, IHC, FACS, IF, LCI et IC.

Aperçu rapide pour KCNN4 anticorps (Extracellular) (PE) (ABIN7581911)

Antigène: KCNN4 (Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KCNN4 est conjugé à/à la PE

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Live Cell Imaging (LCI), Immunochromatography (IC)

Clone: 6C1

Détail du produit anti-KCNN4 anticorps (PE)

Épitope: Extracellular

Fonction: A Mouse Monoclonal Antibody to KCNN4 (KCa3.1, SK4) Channel

Séquence: Synthetic peptide mapping to the 3rd extracellu lar loop of human KCNN4

Specificité: Extracellular loop

Homologie: Recognizes KCNN4 from human,rat,and mouse samples

Attributs du produit: Mouse Anti-KCNN4 (KCa3.1, SK4) (extracellular) Antibody (ABIN7043462 and ABIN7044556) is a highly specific monoclonal antibody directed against an epitope of the human channel. The antibody can be used in western blot, immunocytochemistry, immunohistochemistry, and indirect flow cytometry applications. It has been designed to recognize KCNN4 from human, rat, and mouse samples.  Mouse Anti-KCNN4 (KCa3.1, SK4) (extracellular)-PE Antibody (ABIN7043462 and ABIN7044556-PE) is directly conjugated to R-Phycoerythrin (R-PE) fluorophore. The antibody can be used in immunofluorescent applications such as direct live cell flow cytometry. 

Purification: Affinity purified on immobilized antigen.

Immunogène: Synthetic peptide mapping to the 3rd extracellular loop of human KCNN4

Isotype: IgM

Information d'application

Indications d'application:

Antigen preadsorption control: NA

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: N/A

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 50 μL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur KCNN4

Antigène: KCNN4 (Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4))

Autre désignation: KCNN4

Sujet: IKCa1, IK1, Intermediate conductance Ca2+-activated K+ channel protein 4, Gardos channel,KCa3.1 (KCNN4, SK4) is a member of the Ca2+ activated K+ channel family that shares the characteristic of being activated by intracellular Ca2+. The channel has an intermediate conductance, is voltage insensitive and is activated by Ca2+ in the submicromolar range. The channel has a similar topology to that of KV channels, that is, six transmembrane domains and intracellular N- and C-termini. KCa3.1 is widely expressed in epithelial, endothelial and cells of hematopoietic origin. In erythrocytes (red blood cells) it has been identified as the molecular correlate of the so-called Gardos channel. The functional role of the channel is to set the cell membrane potential at negative values so as to aid in the electrochemical transport of other ions such as Cl- and Ca2+. Indeed, KCa3.1 has a key role in sustaining the Ca2+ influx in activated T lymphocytes and in regulating Cl- secretion from colon epithelium. Therefore, specific blockers of the KCa3.1 channel have been proposed for the treatment of several diseases including autoimmune diseases, secretory diarrhea and sickle cell anemia.

ID gène: 3783

UniProt: O15554