NEGR1 anticorps (Extracellular)

N° du produit ABIN7886646

L’anticorps anti-NEGR1 Polyclonal Lapin est utilisé pour la détection de NEGR1 dans des échantillons de Souris. Il a été validé pour WB, IHC, FACS et LCI.

Aperçu rapide pour NEGR1 anticorps (Extracellular) (ABIN7886646)

Antigène: NEGR1 (Neuronal Growth Regulator 1 (NEGR1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEGR1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-NEGR1 anticorps

Épitope: Extracellular

Fonction: A Rabbit polyclonal antibody to NEGR1 (extracellular).

Séquence: (C)HISPSAKPFE NGQYLD

Homologie: Human,Rat - identical 

Attributs du produit: Anti-NEGR1 (extracellular) Antibody (ABIN7581917) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize NEGR1 from mouse, rat and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)HISPSAKPFENGQYLD, corresponding to amino acid residues 168 -183 of mouse NEGR1

Isotype: IgG

Information d'application

Indications d'application: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur NEGR1

Antigène: NEGR1 (Neuronal Growth Regulator 1 (NEGR1))

Autre désignation: NEGR1

Sujet:

Synonyms: Neuronal Growth Regulator 1, IgLON Family Member 4, IGLON4 

Description: Neuronal growth regulator 1 (NEGR1), also known as neurotractin or Kilon, is a member of the immunoglobulin superfamily's IgLON subgroup. Structurally, IgLON proteins share three Ig-like C2-type domains and are anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor1,2. These proteins are implicated in neural development, supporting cellular interactions, neurite outgrowth, and synaptic formation3,4. NEGR1 is predominantly expressed in brain tissue, especially in the cerebral cortex, hippocampus, and hypothalamus. At the cellular level, it localizes to neuronal cell membranes where it regulates neurite extension and synapse stabilization1,5. NEGR1 activity is regulated through interaction with signaling molecules such as leukemia inhibitory factor receptor (LIFR), which affects downstream factors like lipocalin-2 (Lcn2) that are vital for neurogenesis and affective behaviors3. Functionally, NEGR1 modulates cell adhesion and neurite growth, processes essential for the proper development of neural circuits. It plays roles in both physiological and pathological states, for example, it is linked to hippocampal neurogenesis and synaptic plasticity, influencing behaviors related to anxiety and depression3,5. Dysfunctions in NEGR1 are associated with obesity, learning difficulties, psychiatric disorders, and mood dysregulation. Knockout studies in mice reveal that the loss of NEGR1 leads to reduced body mass, anxiety-like behaviors, and impaired neurogenesis2,4.

ID gène: 320840

Pathways: Feeding Behaviour