NPBWR1 anticorps (Intracellular, Loop 2)

N° du produit ABIN7581920

L’anticorps anti-NPBWR1 Polyclonal Lapin est utilisé pour la détection de NPBWR1 dans des échantillons de Souris. Il a été validé pour WB et IHC.

Aperçu rapide pour NPBWR1 anticorps (Intracellular, Loop 2) (ABIN7581920)

Antigène: NPBWR1 (Neuropeptides B/W Receptor 1 (NPBWR1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NPBWR1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-NPBWR1 anticorps

Épitope: AA 145-158, Intracellular, Loop 2

Fonction: A Rabbit Polyclonal antibody to NPBWR1 receptor

Séquence: (C)ESRRVSGRTY GAAR

Réactivité croisée (Details): The antibody is specific for NPBWR1, it will not recognize the human only receptor NPBWR2.

Homologie: Rat - identical, human - 12 out of 14 amino acid residues identical

Attributs du produit: Anti-NPBWR1 Antibody (ABIN7581920) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize NPBWR1 from rat, mouse and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)ESRRVSGRTYGAAR, corresponding to amino acid residues 145 - 158 of mouse NPBWR1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:400

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur NPBWR1

Antigène: NPBWR1 (Neuropeptides B/W Receptor 1 (NPBWR1))

Autre désignation: NPBWR1

Sujet:

Synonyms: Neuropeptides B/W Receptor Type 1, G Protein-Coupled Receptor 7, GPR7

Description: Neuropeptides B/W receptor type 1 (NPBWR1), also known as G-protein coupled receptor 7 (GPR7), is a member of the G-protein coupled receptor (GPCR) superfamily.NPBWR1 mediates the biological activities of Neuropeptide B (NPB) and neuropeptide W (NPW) that are structurally and functionally related endogenous neuropeptides. In humans, a second receptor termed NPBWR2 or GPR8, has been identified, however, NPBWR2 is absent in rodents.1,2NPBWR1 is expressed in the central nervous system (CNS) and in peripheral tissues. In the brain expression of NPBWR1 is found in several regions including hypothalamus, hippocampus and amygdala. Indeed, the distribution of NPBWR1 and its ligands in brain is in accordance to their established functions in appetite control and feeding behavior, as well as locomotion, analgesia and stress response.2,3Several studies have pointed to the role of NPBWR1 in pain modulation. Interestingly, NPBWR1 has structural similarities with the opioid receptors and in fact, it binds non-selective opioid ligands such as β-endorphin.3 It has been suggested, that a combination therapies of morphine (an opioid receptor ligand) and NPBWR1 agonists could provide a new avenue to treat inflammatory and neuropathic pain with less risk of adverse effects. 4In the periphery, NPBWR1 may be involved in energy homeostasis by regulating insulin secretion from pancreatic β cells and regulating white and brown adipose tissue. 3

ID gène: 226304

UniProt: P49681