TACR1 anticorps (Extracellular) (APC)

N° du produit ABIN7582081

Cet anticorps Lapin Polyclonal détecte spécifiquement TACR1 dans FACS et LCI. Il présente une réactivité envers Rat.

Aperçu rapide pour TACR1 anticorps (Extracellular) (APC) (ABIN7582081)

Antigène: TACR1 (Tachykinin Receptor 1 (TACR1))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TACR1 est conjugé à/à la APC

Application: Flow Cytometry (FACS), Live Cell Imaging (LCI)

Détail du produit anti-TACR1 anticorps (APC)

Épitope: AA 180-194, Extracellular

Fonction: A Rabbit Polyclonal Antibody to Neurokinin 1 Receptor Conjugated to the Fluorescent Dye Allophycocyanin (APC).

Séquence: CMIEWPEHPN RTYEK

Specificité: 2nd extracellular loop

Homologie: Mouse - identical, human - 13,15 amino acid residues identical

Attributs du produit: Anti-Neurokinin 1 Receptor (NK1R) (extracellular) Antibody (ABIN7043803, ABIN7045318 and ABIN7045319) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, indirect live cell flow cytometry, and live cell imaging applications. It has been designed to recognize NK1 receptor from rat, mouse, and human samples. Anti-Neurokinin 1 Receptor (NK1R) (extracellular)-APC Antibody (ABIN7043803, ABIN7045318 and ABIN7045319-APC) is directly conjugated to Allophycocyanin (APC) fluorophore. This conjugated antibody has been developed to be used in immunofluorescent applications such as direct flow cytometry and live cell imaging.

Purification: Affinity purified on immobilized antigen.

Immunogène: CMIEWPEHPNRTYEK, corresponding to amino acid residues 180-194 of rat NK1 receptor 

Isotype: IgG

Information d'application

Indications d'application: Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Commentaires:

Negative Control: (ABIN7582043)

Blocking Peptide: (ABIN7237370)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 15 μL or 50 μL double distilled water (DDW), depending on the sample size.

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur TACR1

Antigène: TACR1 (Tachykinin Receptor 1 (TACR1))

Autre désignation: TACR1

Sujet: NK1 receptor, Tachykinin receptor 1, TACR1, Substance-P receptor, SPR,Substance P (SP), Neurokinin A (NKA) and Neurokinin B (NKB) are all peptides belonging to the Tachykinin protein family. These three peptides, which demonstrate quite a heterogeneity in their distribution, exert their effect via three receptors: Neurokinin 1-3 receptors, members of the G-protein coupled receptor superfamily. However, Neurokinin 1 (NK1) receptor preferentially binds Substance P, Neurokinin 2 (NK2) receptor to NKA, and Neurokinin 3 (NK3) receptor to NKB1.Neurokinin receptors are distinguished by their seven transmembrane domains, an extracellular N-terminus and a cytosolic C-terminal. An unusual property of these receptors is the presence of introns as part of their structural organization1-3. Tachykinin receptors undergo alternative splicing. For example, NK1 receptor is detected with different C-terminal lengths. The longer receptor isoform is found in the brain whereas the truncated form is mostly detected in the periphery1,4.Due to the broad expression profile of tachykinin peptides, their respective receptors are also expressed in a similar fashion. NK1 receptor is widely expressed in neurons, endothelial cells, muscle and immune system cells. NK2 receptor is broadly expressed in the periphery and its expression in the brain is quite restricted. NK3 receptor on the other hand is largely expressed in the central nervous system and is also detected in the uterus, skeletal muscle, lung and liver1.Neurokinin receptors have been found in many pathophysiological indications and have therefore become targets for the development of pharmacological compounds. Such indications include cancer, psychological disorders, migraine and various inflammations, just to name a few5-8.

ID gène: 24807

UniProt: P14600

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration