GRIK1 anticorps (AA 824-1203)

N° du produit ABIN7595945

Cet anticorps Souris Monoclonal détecte spécifiquement GRIK1 dans WB, IHC, ICC et IP. Il présente une réactivité envers Rat.

Aperçu rapide pour GRIK1 anticorps (AA 824-1203) (ABIN7595945)

Antigène: GRIK1 (Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1))

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GRIK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Clone: N75-33

Détail du produit anti-GRIK1 anticorps

Épitope: AA 824-1203

Fonction: Anti-mGluR1/5 (Group I) Glutamate Receptor Antibody

Specificité: Recognizes mGluR1 and mGluR5

Réactivité croisée: Humain, Souris, Rat

Attributs du produit:

Description: Our Anti-mGluR1/5 (Group I) glutamate receptor mouse monoclonal primary antibody is produced in-house from hybridoma clone N75/33. It detects human, mouse, and rat mGluR1/5 (Group I) glutamate receptor, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.

Manufacturer Comment: We produce our mGluR1/5 (Group I) glutamate receptor mouse monoclonal primary antibody from hybridoma clone N75/33. It is great in IHC, ICC, IP, WB and is purified by Protein A chromatography.

Purification: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography.

Pureté: > 90 % specific antibody

Immunogène: Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b (accession number P31424) produced recombinantly in E. Coli

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 10 mM Tris, 50 mM Sodium Chloride, 0.065 % Sodium Azide pH 7.44

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Date de péremption: 24 months

Détails sur GRIK1

Antigène: GRIK1 (Glutamate Receptor, Ionotropic, Kainate 1 (GRIK1))

Autre désignation: 5 glutamate receptor

Sujet:

Synonyms: Metabotropic glutamate receptor 5 (mGluR5)

Target Description: The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004, Francesconi et al., 2004, Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003). In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA1 of the hippocampus (Francesconi et al., 2004).

Gene Name Alternatives: Grm5 Gprc1e Mglur5

Poids moléculaire: 130 kDa (both mGluR1 and mGluR5)

Pathways: Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity