NDUFV2 anticorps (AA 1-249)

N° du produit ABIN7599154

Cet anticorps Lapin Polyclonal détecte spécifiquement NDUFV2 dans WB, ELISA, IHC, IF et FACS. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour NDUFV2 anticorps (AA 1-249) (ABIN7599154)

Antigène: NDUFV2 (NADH Dehydrogenase (Ubiquinone) Flavoprotein 2, 24kDa (NDUFV2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NDUFV2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-NDUFV2 anticorps

Épitope: AA 1-249

Fonction: Anti-NDUFV2 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-NDUFV2 Antibody Picoband® (ABIN7599154). Tested in ELISA, Flow Cytometry, IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human NDUFV2 recombinant protein (Position: M1-L249).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.25 μg/mL/mL, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL/mL, Human
Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/mL/1x10^6 cells, Human
ELISA, 0.1-0.5 μg/mL/mL, Human
1. Benit, P., Beugnot, R., Chretien, D., Giurgea, I., De Lonlay-Debeney, P., Issartel, J.-P., Corral-Debrinski, M., Kerscher, S., Rustin, P., Rotig, A., Munnich, A. Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathy. Hum. Mutat. 21: 582-586, 2003. 2. Cameron, J. M., MacKay, N., Feigenbaum, A., Tarnopolsky, M., Blaser, S., Robinson, B. H., Schulze, A. Exome sequencing identifies complex I NDUFV2 mutations as a novel cause of Leigh syndrome. Europ. J. Paediat. Neurol. 19: 525-532, 2015. 3. de Coo, R., Buddiger, P., Smeets, H., Geurts van Kessel, A., Morgan-Hughes, J., Weghuis, D. O., Overhauser, J., van Oost, B. Molecular cloning and characterization of the active human mitochondrial NADH:ubiquinone oxidoreductase 24- kDa gene (NDUFV2) and its pseudogene. Genomics 26: 461-466, 1995.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur NDUFV2

Antigène: NDUFV2 (NADH Dehydrogenase (Ubiquinone) Flavoprotein 2, 24kDa (NDUFV2))

Autre désignation: NDUFV2

Sujet:

Synonyms: Ubiquitin carboxyl-terminal hydrolase 16, Deubiquitinating enzyme 16, Ubiquitin thioesterase 16, Ubiquitin-processing protease UBP-M, Ubiquitin-specific-processing protease 16, USP16, MSTP039

Tissue Specificity: Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Background: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (NDUFV2) is an enzyme that in humans is encoded by the NDUFV2 gene. The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes the 24 kDa subunit of complex I, and is involved in electron transfer. Mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A non-transcribed pseudogene of this locus is found on chromosome 19.

Poids moléculaire: 27 kDa

ID gène: 4729

UniProt: P19404