PFKFB4 anticorps (AA 1-298)

N° du produit ABIN7599238

Cet anticorps Lapin Polyclonal détecte spécifiquement PFKFB4 dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PFKFB4 anticorps (AA 1-298) (ABIN7599238)

Antigène: PFKFB4 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PFKFB4 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-PFKFB4 anticorps

Épitope: AA 1-298

Fonction: Anti-PFKFB4 Antibody

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Human PFKFB4 shares 97.3%,97% amino acid (aa) sequence identity with mouse,rat PFKFB4,respectively.

Attributs du produit: Anti-PFKFB4 Antibody. Tested in WB, ELISA applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PFKFB4 recombinant protein (Position: M1-K298). Human PFKFB4 shares 97.3% and 97% amino acid (aa) sequence identity with mouse and rat PFKFB4, respectively.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur PFKFB4

Antigène: PFKFB4 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 4 (PFKFB4))

Autre désignation: PFKFB4

Sujet:

Background: 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4 also known as PFKFB4 is an enzyme which in humans is encoded by the PFKFB4 gene. The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2, 6-bisphosphate (F2, 6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2, 6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

Poids moléculaire: 54 kDa

ID gène: 5210

UniProt: Q16877