CARD9 anticorps (AA 1-429)

N° du produit ABIN7599386

L’anticorps Lapin Polyclonal anti-CARD9 a été validé pour WB, IHC, ELISA, ICC, IF et FACS. Il convient pour détecter CARD9 dans des échantillons de Humain.

Aperçu rapide pour CARD9 anticorps (AA 1-429) (ABIN7599386)

Antigène: CARD9 (Caspase Recruitment Domain Family, Member 9 (CARD9))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CARD9 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-CARD9 anticorps

Épitope: AA 1-429

Fonction: Anti-CARD9 Picoband® Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-CARD9 Picoband® Antibody (ABIN7599386). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human CARD9 recombinant protein (Position: M1-D429).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Hsu, Y.-M. S., Zhang, Y., You, Y., Wang, D., Li, H., Duramad, O., Qin, X.-F., Dong, C., Lin, X. The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nature Immun. 8: 198-205, 2007. 2. Lanternier, F., Pathan, S., Vincent, Q. B., Liu, L., Cypowyj, S., Prando, C., Migaud, M., Taibi, L., Ammar-Khodja, A., Boudghene Stambouli, O., Guellil, B., Jacobs, F., and 21 others. Deep dermatophytosis and inherited CARD9 deficiency. New Eng. J. Med. 369: 1704-1714, 2013. 3. Yang, H., Minamishima, Y. A., Yan, Q., Schlisio, S., Ebert, B. L., Zhang, X., Zhang, L., Kim, W. Y., Olumi, A. F., Kaelin, W. G., Jr. pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappa-B agonist Card9 by CK2. Molec. Cell 28: 15-27, 2007.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur CARD9

Antigène: CARD9 (Caspase Recruitment Domain Family, Member 9 (CARD9))

Autre désignation: CARD9

Sujet:

Synonyms: Caspase recruitment domain-containing protein 9. Hcard9. CARD9

Tissue Specificity: Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts.

Background: Caspase recruitment domain-containing protein 9 is an adaptor protein of the CARD-CC protein family, which in humans is encoded by the CARD9 gene. It is mapped to 9q34.3. The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined.

Poids moléculaire: 63 kDa

ID gène: 64170

UniProt: Q9H257

Pathways: Activation of Innate immune Response