NBR1 anticorps (AA 1-665)

N° du produit ABIN7599518

L’anticorps Lapin Polyclonal anti-NBR1 a été validé pour WB, ELISA, IF, FACS et ICC. Il convient pour détecter NBR1 dans des échantillons de Humain et Singe.

Aperçu rapide pour NBR1 anticorps (AA 1-665) (ABIN7599518)

Antigène: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Reactivité: Humain, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NBR1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Détail du produit anti-NBR1 anticorps

Épitope: AA 1-665

Fonction: Anti-NBR1 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-NBR1 Antibody Picoband® (ABIN7599518). Tested in ELISA, IF, ICC, WB, Flow Cytometry applications. This antibody reacts with Human, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human NBR1 recombinant protein (Position: M1-H665).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Monkey
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Brown, M. A., Nicolai, H., Xu, C.-F., Griffiths, B. L., Jones, K. A., Solomon, E., Hosking, L., Trowsdale, J., Black, D. M., McFarlane, R. Regulation of BRCA1. (Letter) Nature 372: 733 only, 1994. 2. Brown, M. A., Xu, C.-F., Nicolai, H., Griffiths, B., Chambers, J. A., Black, D., Solomon, E. The 5-prime end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21. Oncogene 12: 2507-2513, 1996. 3. Campbell, I. G., Nicolai, H. M., Foulkes, W. D., Senger, G., Stamp, G. W., Allan, G., Boyer, C., Jones, K., Bast, R. C., Jr., Solomon, E., Trowsdale, J., Black, D. M. A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1. Hum. Molec. Genet. 3: 589-594, 1994.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur NBR1

Antigène: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Autre désignation: NBR1

Sujet:

Synonyms: Segment polarity protein dishevelled homolog DVL-1,Dishevelled-1,DSH homolog 1,DVL1,

Tissue Specificity: Found in embryos and in adult liver and heart.

Background: Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene. The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants.

Poids moléculaire: 140 kDa

ID gène: 4077

UniProt: Q14596

Pathways: Autophagy