CHI3L1 anticorps (AA 103-383)

N° du produit ABIN7599648

Cet anticorps anti-CHI3L1 est un anticorps Lapin Polyclonal détectant CHI3L1 dans WB, ICC, ELISA et IF. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour CHI3L1 anticorps (AA 103-383) (ABIN7599648)

Antigène: CHI3L1 (Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHI3L1 est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC), ELISA, Immunofluorescence (IF)

Détail du produit anti-CHI3L1 anticorps

Épitope: AA 103-383

Fonction: Anti-YKL-40/CHI3L1 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-YKL-40/CHI3L1 Antibody Picoband® (ABIN7599648). Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human YKL-40/CHI3L1 recombinant protein (Position: S103-T383).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Chung, C., Tallerico, T., Seeman, P. Schizophrenia hippocampus has elevated expression of chondrex glycoprotein gene. Synapse 50: 29-34, 2003. 2. Hakala, B. E., White, C., Recklies, A. D. Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. J. Biol. Chem. 268: 25803-25810, 1993. 3. Ober, C., Tan, Z., Sun, Y., Possick, J. D., Pan, L., Nicolae, R., Radford, S., Parry, R. R., Heinzmann, A., Deichmann, K. A., Lester, L. A., Gern, J. E., Lemanske, R. F., Jr., Nicolae, D. L., Elias, J. A., Chupp, G. L. Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. New Eng. J. Med. 358: 1682-1691, 2008.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur CHI3L1

Antigène: CHI3L1 (Chitinase 3-Like 1 (Cartilage Glycoprotein-39) (CHI3L1))

Autre désignation: CHI3L1

Sujet:

Synonyms: Chitinase-3-like protein 1, BRP39 protein, Breast regression protein 39, Cartilage glycoprotein 39, CGP-39, GP-39, Chi3l1, Brp39, Chil1,

Tissue Specificity: Detected in lung in pulmonary macrophages and alveolar type 2 cells and in bronchoalveolar lavage (BAL) fluids. Expressed in mammary tumor cells (at protein level). Expressed in lung. Not detected in non-inflammatory colon.

Background: Chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, is a secreted glycoprotein that is approximately 40 kDa in size that in humans is encoded by the CHI3L1 gene. Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling.

Poids moléculaire: 43 kDa

ID gène: 1116

UniProt: P36222