KIF1A anticorps (AA 1079-1628)

N° du produit ABIN7599679

Cet anticorps Lapin Polyclonal détecte spécifiquement KIF1A dans ELISA, WB et FACS. Il présente une réactivité envers Souris, Humain et Rat.

Aperçu rapide pour KIF1A anticorps (AA 1079-1628) (ABIN7599679)

Antigène: KIF1A (Kinesin Family Member 1A (KIF1A))

Reactivité: Souris, Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KIF1A est non-conjugé

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit anti-KIF1A anticorps

Épitope: AA 1079-1628

Fonction: Anti-KIF1A Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-KIF1A Antibody Picoband® (ABIN7599679). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human KIF1A recombinant protein (Position: H1079-Y1628).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Chiba, K., Takahashi, H., Chen, M., Obinata, H., Arai, S., Hashimoto, K., Oda, T., McKenney, R. J., Niwa, S. Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors. Proc. Nat. Acad. Sci. 116: 18429-18434, 2019. 2. Citterio, A., Arnoldi, A., Panzeri, E., Merlini, L., D'Angelo, M. G., Musumeci, O., Toscano, A., Bondi, A., Martinuzzi, A., Bresolin, N., Bassi, M. T. Variants in KIF1A gene in dominant and sporadic forms of hereditary spastic paraparesis. J. Neurol. 262: 2684-2690, 2015. 3. Erlich, Y., Edvardson, S., Hodges, E., Zenvirt, S., Thekkat, P., Shaag, A., Dor, T., Hannon, G. J., Elpeleg, O. Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis. Genome Res. 21: 658-664, 2011.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur KIF1A

Antigène: KIF1A (Kinesin Family Member 1A (KIF1A))

Autre désignation: KIF1A

Sujet:

Synonyms: S-arrestin, 48 kDa protein, Retinal S-antigen, S-AG, Rod photoreceptor arrestin, SAG,

Tissue Specificity: Retina and pineal gland.

Background: Kinesin-like protein KIF1A, also known as axonal transporter of synaptic vesicles or microtubule-based motor KIF1A, is a protein that in humans is encoded by the KIF1A gene. The protein encoded by this gene is a member of the kinesin family and functions as an anterograde motor protein that transports membranous organelles along axonal microtubules. Mutations at this locus have been associated with spastic paraplegia-30 and hereditary sensory neuropathy IIC. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Poids moléculaire: 191 kDa

ID gène: 547

UniProt: Q12756