SLFN11 anticorps (AA 114-794)

N° du produit ABIN7599761

L’anticorps Lapin Polyclonal anti-SLFN11 a été validé pour ELISA, WB, IHC et FACS. Il convient pour détecter SLFN11 dans des échantillons de Humain.

Aperçu rapide pour SLFN11 anticorps (AA 114-794) (ABIN7599761)

Antigène: SLFN11 (Schlafen Family Member 11 (SLFN11))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLFN11 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Détail du produit anti-SLFN11 anticorps

Épitope: AA 114-794

Fonction: Anti-SLFN11 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-SLFN11 Antibody Picoband® (ABIN7599761). Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human SLFN11 recombinant protein (Position: P114-D794).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Bustos, O., Naik, S., Ayers, G., Casola, C., Perez-Lamigueiro, M. A., Chippindale, P. T., Pritham, E. J., de la Casa-Esperon, E. Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes, and orthopoxvirus virulence. Gene 447: 1-11, 2009. 2. Geserick, P., Kaiser, F., Klemm, U., Kaufmann, S. H. E., Zerrahn, J. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Int. Immun. 16: 1535-1548, 2004. 3. Gross, M. B. Personal Communication. Baltimore, Md. 11/29/2012.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur SLFN11

Antigène: SLFN11 (Schlafen Family Member 11 (SLFN11))

Autre désignation: SLFN11

Sujet:

Synonyms: Neuropeptides B/W receptor type 1, G-protein coupled receptor 7, NPBWR1, GPR7

Tissue Specificity: Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea, at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high levels in lung carcinoma.

Background: Schlafen family member 11 is a protein that in humans is encoded by the SLFN11 gene. SLFN11 is a nuclear protein that belongs to the Schlafen (SLFN) family of genes involved in cell cycle regulation and growth inhibition. Expression of SLFN11 predicts sensitivity of cancer cell lines to DNA-damaging agents. Evidence suggests that in the presence of DNA-targeted therapies, SLFN11 is recruited to stressed replication forks where it blocks replication leading to cell death. SLFN11 is being explored as a predictive biomarker for response to DNA-targeted therapies.

Poids moléculaire: 103 kDa

ID gène: 91607

UniProt: Q7Z7L1