MVK anticorps (AA 13-394)

N° du produit ABIN7599941

Cet anticorps Lapin Polyclonal détecte spécifiquement MVK dans WB, IHC, ELISA, IF, FACS et ICC. Il présente une réactivité envers Humain.

Aperçu rapide pour MVK anticorps (AA 13-394) (ABIN7599941)

Antigène: MVK (Mevalonate Kinase (MVK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MVK est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Détail du produit anti-MVK anticorps

Épitope: AA 13-394

Fonction: Anti-MVK Antibody Picoband®

Attributs du produit: Anti-MVK Antibody Picoband® (ABIN7599941). Tested in WB, IHC, ICC/IF, Flow Cytometry, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human MVK recombinant protein (Position: K13-D394). Human MVK shares 80.8% and 81.4% amino acid (aa) sequence identity with mouse and rat MVK, respectively.

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry, 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Balgobind, B., Wittebol-Post, D., Frenkel, J. Retinitis pigmentosa in mevalonate kinase deficiency. J. Inherit. Metab. Dis. 28: 1143-1145, 2005. 2. Brito, T., Banganho, D., Pedrosa, C., Neves, J. F. Homozygous V377I mutation causing mevalonate kinase. BMJ Case Rep. 15: e249135, 2022. 3. Cuisset, L., Drenth, J. P. H., Simon, A., Vincent, M. F., van der Velde Visser, S., van der Meer, J. W. M., Grateau, G., Delpech, M., International Hyper-IgD Study Group. Molecular analysis of MVK mutations and enzymatic activity in hyper-IgD and periodic fever syndrome. Europ. J. Hum. Genet. 9: 260-266, 2001.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur MVK

Antigène: MVK (Mevalonate Kinase (MVK))

Autre désignation: MVK

Sujet: This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 42 kDa

ID gène: 4598

UniProt: Q03426