L1CAM anticorps (AA 20-242)

N° du produit ABIN7600528

L’anticorps Lapin Polyclonal anti-L1CAM a été validé pour WB et ELISA. Il convient pour détecter L1CAM dans des échantillons de Humain.

Aperçu rapide pour L1CAM anticorps (AA 20-242) (ABIN7600528)

Antigène: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp L1CAM est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-L1CAM anticorps

Épitope: AA 20-242

Fonction: Anti-L1CAM Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-L1CAM Antibody Picoband® (ABIN7600528). Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human L1CAM recombinant protein (Position: I20-L242).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Basel-Vanagaite, L., Straussberg, R., Friez, M. J., Inbar, D., Korenreich, L., Shohat, M., Schwartz, C. E. Expanding the phenotypic spectrum of L1CAM-associated disease. Clin. Genet. 69: 414-419, 2006. 2. Du, Y.-Z., Dickerson, C., Aylsworth, A. S., Schwartz, C. E. A silent mutation, C924T (G308G), in the L1CAM gene results in X linked hydrocephalus (HSAS). J. Med. Genet. 35: 456-462, 1998.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur L1CAM

Antigène: L1CAM (L1 Cell Adhesion Molecule (L1CAM))

Autre désignation: L1CAM

Sujet:

Synonyms: Neural cell adhesion molecule L1, N-CAM-L1, NCAM-L1, CD171, L1CAM, CAML1, MIC5

Tissue Specificity: Ubiquitous. Highest expression seen in the heart and skeletal muscle.

Background: L1, also known as L1CAM, is a transmembrane protein member of the L1 protein family, encoded by the L1CAM gene. The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.

Poids moléculaire: 250 kDa

ID gène: 3897

UniProt: P32004

Pathways: Synaptic Membrane