CD1d anticorps (AA 20-295)

N° du produit ABIN7600538

Cet anticorps anti-CD1d est un anticorps Lapin Polyclonal détectant CD1d dans FACS, WB et ELISA. Adapté pour Humain et Rat.

Aperçu rapide pour CD1d anticorps (AA 20-295) (ABIN7600538)

Antigène: CD1d (CD1D) (CD1d Molecule (CD1D))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD1d est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA

Détail du produit anti-CD1d anticorps

Épitope: AA 20-295

Fonction: Anti-CD1D Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-CD1D Antibody Picoband® (ABIN7600538). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human CD1D recombinant protein (Position: E20-W295).

Isotype: IgG

Information d'application

Indications d'application: "Western blot, 0.25-0.5 μg/mL, Human, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
"1. Jayawardena-Wolf, J., Benlagha, K., Chiu, Y.-H., Mehr, R., Bendelac, A. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain.Immunity 15: 897-908, 2001.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur CD1d

Antigène: CD1d (CD1D) (CD1d Molecule (CD1D))

Autre désignation: CD1D

Sujet:

Synonyms: Antigen-presenting glycoprotein CD1d; R3G1; CD1d; CD1D

Tissue Specificity: Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Background: CD1D (CD1d molecule) also known as R3G1, Antigen-presenting glycoprotein CD1d, R3G1, CD1D, is the sole group-2 member of the CD1 family of major histocompatibility (MHC)-like glycoproteins. Expressed on the surface of various human antigen-presenting cells. They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T cells. It is the only member of the group 2 CD1 molecules. CD1d presented lipid antigens activate a special class of T cells, known as Natural Killer T (NKT) cells. When activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and IL-4 production. Jayawardena-Wolf et al. described 2 different pathways of Cd1d trafficking to endosomal compartments in mouse cells. A tyrosine-based motif governs recycling between the plasma membrane and the endosome, while Cd1d associates, like major histocompatibility complex class II antigens, with the invariant chain, or II, in the endoplasmic reticulum. Both pathways enhance antigen presentation to Cd1d-restricted natural killer T cells.

Poids moléculaire: 55 kDa

ID gène: 912

UniProt: P15813

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process