PLA2R1 anticorps (AA 21-66)

N° du produit ABIN7600628

Cet anticorps anti-PLA2R1 est un anticorps Lapin Polyclonal détectant PLA2R1 dans WB et ELISA. Adapté pour Humain.

Aperçu rapide pour PLA2R1 anticorps (AA 21-66) (ABIN7600628)

Antigène: PLA2R1 (phospholipase A2 Receptor 1, 180kDa (PLA2R1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PLA2R1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-PLA2R1 anticorps

Épitope: AA 21-66

Fonction: Anti-PLA2R/PLA2R1 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-PLA2R/PLA2R1 Antibody Picoband® (ABIN7600628). Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PLA2R/PLA2R1 recombinant protein (Position: E21-Q66).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Ancian, P., Lambeau, G., Mattei, M.-G., Lazdunski, M. The human 180- kDa receptor for secretory phospholipases A2: molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization. J. Biol. Chem. 270: 8963-8970, 1995. 2. Beck, L. H., Jr., Bonegio, R. G. B., Lambeau, G., Beck, D. M., Powell, D. W., Cummins, T. D., Klein, J. B., Salant, D. J. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. New Eng. J. Med. 361: 11-21, 2009. 3. Debiec, H., Ronco, P. PLA2R autoantibodies and PLA2R glomerular deposits in membranous nephropathy. (Letter) New Eng. J. Med. 364: 689-690, 2011.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur PLA2R1

Antigène: PLA2R1 (phospholipase A2 Receptor 1, 180kDa (PLA2R1))

Autre désignation: PLA2R1

Sujet:

Synonyms: Interleukin-25, IL-25, Interleukin-17E, IL-17E, IL25, IL17E, UNQ3120/PRO10272

Tissue Specificity: Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.

Background: Secretory phospholipase A2 receptor is an enzyme that in humans is encoded by the PLA2R1 gene. This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.

Poids moléculaire: 169 kDa

ID gène: 22925

UniProt: Q13018

Pathways: Positive Regulation of Response to DNA Damage Stimulus