PMVK anticorps (AA 22-192)

N° du produit ABIN7600680

Cet anticorps Lapin Polyclonal détecte spécifiquement PMVK dans WB et ELISA. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour PMVK anticorps (AA 22-192) (ABIN7600680)

Antigène: PMVK (Phosphomevalonate Kinase (PMVK))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PMVK est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-PMVK anticorps

Épitope: AA 22-192

Fonction: Anti-PMVK Antibody Picoband®

Attributs du produit: Anti-PMVK Antibody Picoband® (ABIN7600680). Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PMVK recombinant protein (Position: K22-L192). Human PMVK shares 82.5% amino acid (aa) sequence identity with mouse PMVK.

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Mouse
ELISA, 0.1-0.5 μg/mL, -
1. Chambliss, K. L., Slaughter, C. A., Schreiner, R., Hoffmann, G. F., Gibson, K. M. Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence. J. Biol. Chem. 271: 17330-17334, 1996. 2. Olivier, L. M., Chambliss, K. L., Gibson, K. M., Krisans, S. K. Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting. J. Lipid Res. 40: 672-679, 1999. 3. Zhang, Z., Li, C., Wu, F., Ma, R., Luan, J., Yang, F., Liu, W., Wang, L., Zhang, S., Liu, Y., Gu, J., Hua, W., and 13 others. Genomic variations of the mevalonate pathway in porokeratosis. eLife 4: e06322, 2015. Note: Electronic Article. Erratum: eLife 5: e14383, 2016.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur PMVK

Antigène: PMVK (Phosphomevalonate Kinase (PMVK))

Autre désignation: PMVK

Sujet: This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 22 kDa

ID gène: 10654

UniProt: Q15126