Innate Immunity Activator Protein (C1ORF106) (AA 236-663) anticorps

N° du produit ABIN7600790

Cet anticorps anti-Innate Immunity Activator Protein est un anticorps Polyclonal produit chez le Lapin, détectant Innate Immunity Activator Protein dans ELISA et WB. Convient pour Humain.

Aperçu rapide pour Innate Immunity Activator Protein (C1ORF106) (AA 236-663) anticorps (ABIN7600790)

Antigène: Innate Immunity Activator Protein (C1ORF106)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: ELISA, Western Blotting (WB)

Détail du produit

Épitope: AA 236-663

Fonction: Anti-INAVA Antibody

Attributs du produit: Anti-INAVA Antibody (ABIN7600790). Tested in WB, ELISA applications. This antibody reacts with Human. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human INAVA recombinant protein (Position: Q236-V663). Human INAVA shares 85.3% amino acid (aa) sequence identity with mouse INAVA.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détail du antigène

Antigène: Innate Immunity Activator Protein (C1ORF106)

Autre désignation: INAVA

Sujet: INAVA, sometimes referred to as hypothetical protein LOC55765, is a protein of unknown function that in humans is encoded by the INAVA gene. Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262).

Poids moléculaire: 70 kDa

ID gène: 55765