PIGV anticorps (AA 26-470)

N° du produit ABIN7600964

Cet anticorps anti-PIGV est un anticorps Lapin Polyclonal détectant PIGV dans ELISA, WB et FACS. Adapté pour Humain.

Aperçu rapide pour PIGV anticorps (AA 26-470) (ABIN7600964)

Antigène: PIGV (Phosphatidylinositol Glycan Anchor Biosynthesis, Class V (PIGV))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIGV est non-conjugé

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit anti-PIGV anticorps

Épitope: AA 26-470

Fonction: Anti-PIGV Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-PIGV Antibody Picoband® (ABIN7600964). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PIGV recombinant protein (Position: Q26-Y470).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Horn, D., Krawitz, P., Mannhardt, A., Korenke, G. C., Meinecke, P. Hyperphosphatasia-mental retardation syndrome due to PIGV mutations: expanded clinical spectrum. Am. J. Med. Genet. 155A: 1917-1922, 2011. 2. Kang, J. Y. Hong, Y., Ashida, H., Shishioh, N., Murakami, Y., Morita, Y. S., Maeda, Y., Kinoshita, T. PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol. J. Biol. Chem. 280: 9489-9497, 2005. 3. Krawitz, P. M., Schweiger, M. R., Rodelsperger, C., Marcelis, C., Kolsch, U., Meisel, C., Stephani, F., Kinoshita, T., Murakami, Y., Bauer, S., Isau, M., Fischer, A., and 17 others. Identity-by-descent filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrome. Nature Genet. 42: 827-829, 2010.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur PIGV

Antigène: PIGV (Phosphatidylinositol Glycan Anchor Biosynthesis, Class V (PIGV))

Autre désignation: PIGV

Sujet:

Synonyms: RecQ-mediated genome instability protein 2, hRMI2, BLM-associated protein of 18 kDa, BLAP18, RMI2, C16orf75

Background: GPI mannosyltransferase 2 is an enzyme that in humans is encoded by the PIGV gene. This gene encodes a mannosyltransferase enzyme involved in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a complex glycolipid that functions as a membrane anchor for many proteins and plays a role in multiple cellular processes including protein sorting and signal transduction. The encoded protein is localized to the endoplasmic reticulum and transfers the second mannose to the GPI backbone. Mutations in this gene are associated with hyperphosphatasia cognitive disability syndrome. Alternatively spliced transcript variants have been observed for this gene.

Poids moléculaire: 60 kDa

ID gène: 55650

Pathways: Inositol Metabolic Process