SCARA5 anticorps (AA 31-288)

N° du produit ABIN7601260

L’anticorps Lapin Polyclonal anti-SCARA5 a été validé pour ELISA et WB. Il convient pour détecter SCARA5 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SCARA5 anticorps (AA 31-288) (ABIN7601260)

Antigène: SCARA5 (Scavenger Receptor Class A, Member 5 (SCARA5))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SCARA5 est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-SCARA5 anticorps

Épitope: AA 31-288

Fonction: Anti-SCARA5 Antibody Picoband®

Attributs du produit: Anti-SCARA5 Antibody Picoband® (ABIN7601260). Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human SCARA5 recombinant protein (Position: K31-R288). Human SCARA5 shares 89.9% amino acid (aa) sequence identity with mouse SCARA5.

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Huang, J., Zheng, D.-L., Qin, F.-S., Cheng, N., Chen, H., Wan, B.-B., Wang, Y.-P., Xiao, H.-S., Han, Z.-G. Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling. J. Clin. Invest. 120: 223-241, 2010. 2. Jiang, Y., Oliver, P., Davies, K. E., Platt, N. Identification and characterization of murine SCARA5, a novel class A scavenger receptor that is expressed by populations of epithelial cells. J. Biol. Chem. 281: 11834-11845, 2006.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur SCARA5

Antigène: SCARA5 (Scavenger Receptor Class A, Member 5 (SCARA5))

Autre désignation: SCARA5

Sujet: Scavenger receptor A5 (SCARA5) is also known as testis expressed scavenger receptor (Tesr). Class A scavenger receptors, including CL-P1, MARCO, SCARA3, and SR-A1, are type II transmembrane proteins that contain a collagenous stalk. Mature human SCARA5 consists of a 60 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 414 aa extracellular domain (ECD) with a spacer, a collagen-like, and a scavenger receptor cysteine-rich (SRCR) domain. Within the ECD, human SCARA5 shares 87 % aa sequence identity with mouse and rat SCARA5. It shares 23 %?34 % aa sequence identity with CL-P1, MARCO, SCARA3, and SR-A1. Alternate splicing generates isoforms that lack the SRCR domain, the transmembrane segment, or the 225 aa spacer region between the membrane and the collagen-like domain. SCARA5 is a cell surface disulfide-linked homotrimer of > 250 kDa. It is highly expressed in testicular Sertoli and germ cells and more weakly in the epithelia of other tissues. During mouse development, SCARA5 expression is attenuated in female embryos at the time of sex determination, whereas it is maintained in the developing testis. SCARA5 is re-expressed in the adult ovary. SCARA5 binds heat-killed bacterial particles but not yeast particles or modified LDL.

Poids moléculaire: 50 kDa

ID gène: 286133

Pathways: Transition Metal Ion Homeostasis