Tpp2 anticorps (AA 32-1001)

N° du produit ABIN7601293

L’anticorps Lapin Polyclonal anti-Tpp2 a été validé pour WB, IF, IHC, ELISA, FACS et ICC. Il convient pour détecter Tpp2 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Tpp2 anticorps (AA 32-1001) (ABIN7601293)

Antigène: Tpp2 (Tripeptidyl Peptidase II (Tpp2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Tpp2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Détail du produit anti-Tpp2 anticorps

Épitope: AA 32-1001

Fonction: Anti-Tripeptidyl peptidase II/TPPII/TPP2 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Tripeptidyl peptidase II/TPPII/TPP2 Antibody Picoband® (ABIN7601293). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Tripeptidyl peptidase II/TPPII/TPP2 recombinant protein (Position: E32-K1001).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Atallah, I., Quinodoz, M., Campos-Xavier, B., Peter, V. G., Fouriki, A., Bonvin, C., Bottani, A., Kumps, C., Angelini, F., Bellutti Enders, F., Christen-Zaech, S., Rizzi, M., and 11 others. Immune deficiency, autoimmune disease and intellectual disability: a pleiotropic disorder caused by biallelic variants in the TPP2 gene. Clin. Genet. 99: 780-788, 2021. 2. Balow, R.-M., Ragnarsson, U., Zetterqvist, O. Tripeptidyl aminopeptidase in the extralysosomal fraction of rat liver. J. Biol. Chem. 258: 11622-11628, 1983. 3. Bermingham, N. A., McKay, T., Hoyle, J., Hernandez, D., Martin, J. E., Fisher, E. M. C. The gene encoding tripeptidyl peptidase II maps to chromosome 1 in the mouse. Mammalian Genome 7: 390 only, 1996.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur Tpp2

Antigène: Tpp2 (Tripeptidyl Peptidase II (Tpp2))

Autre désignation: TPP2

Sujet:

Synonyms: Ubiquitin carboxyl-terminal hydrolase 21, Deubiquitinating enzyme 21, Ubiquitin thioesterase 21, Ubiquitin-specific-processing protease 21, USP21, USP23, PP1490

Tissue Specificity: Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.

Background: Tripeptidyl-peptidase 2 is an enzyme that in humans is encoded by the TPP2 gene. This gene encodes a mammalian peptidase that, at neutral pH , removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase, the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class.

Poids moléculaire: 138 kDa

ID gène: 7174

UniProt: P29144