ITM2C anticorps (AA 33-226)

N° du produit ABIN7601343

Cet anticorps Lapin Polyclonal détecte spécifiquement ITM2C dans WB, ELISA et FACS. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour ITM2C anticorps (AA 33-226) (ABIN7601343)

Antigène: ITM2C (Integral Membrane Protein 2C (ITM2C))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ITM2C est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-ITM2C anticorps

Épitope: AA 33-226

Fonction: Anti-ITM2C Antibody Picoband®

Attributs du produit: Anti-ITM2C Antibody Picoband® (ABIN7601343). Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human ITM2C recombinant protein (Position: E33-D226). Human ITM2C shares 94.8% amino acid (aa) sequence identity with mouse and rat ITM2C.

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Vidal, R., Calero, M., Revesz, T., Plant, G., Ghiso, J., Frangione, B. Sequence, genomic structure and tissue expression of human BRI(3), a member of the BRI gene family. Gene 266: 95-102, 2001. 2. Wickham, L., Benjannet, S., Marcinkiewicz, E., Chretien, M., Seidah, N. G. Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI(3): binding partners processed by furin. J. Neurochem. 92: 93-102, 2005.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur ITM2C

Antigène: ITM2C (Integral Membrane Protein 2C (ITM2C))

Autre désignation: ITM2C

Sujet: Integral membrane protein 2C is a protein that in humans is encoded by the ITM2C gene. The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.

Poids moléculaire: 35 kDa

ID gène: 81618