ANTXR1 anticorps (AA 33-301)

N° du produit ABIN7601347

L’anticorps Lapin Polyclonal anti-ANTXR1 a été validé pour WB et ELISA. Il convient pour détecter ANTXR1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour ANTXR1 anticorps (AA 33-301) (ABIN7601347)

Antigène: ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ANTXR1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-ANTXR1 anticorps

Épitope: AA 33-301

Fonction: Anti-TEM8/ATR/ANTXR1 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-TEM8/ATR/ANTXR1 Antibody Picoband® (ABIN7601347). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human TEM8/ATR/ANTXR1 recombinant protein (Position: E33-D301).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Baxova, A., Kozlowski, K., Obersztyn, E., Zeman, J. GAPO syndrome (radiographic clues to early diagnosis). Radiol. Med. 93: 289-291, 1997. 2. Bayram, Y., Pehlivan, D., Karaca, E., Gambin, T., Jhangiani, S. N., Erdin, S., Gonzaga-Jauregui, C., Wiszniewski, W., Muzny, D., Baylor-Hopkins Center for Mendelian Genomics, Elcioglu, N. H., Yildirim, M. S., Bozkurt, B., Zamani, A. G., Boerwinkle, E., Gibbs, R. A., Lupski, J. R.. Whole exome sequencing identifies three novel mutations in ANTXR1 in families with GAPO syndrome. Am. J. Med. Genet. 164A: 2328-2334, 2014. 3. Besschetnova, T. Y., Ichimura, T., Katebi, N., St. Croix, B., Bonventre, J. V., Olsen, B. R. Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis. Matrix Biol. 42: 56-73, 2015.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur ANTXR1

Antigène: ANTXR1 (anthrax Toxin Receptor 1 (ANTXR1))

Autre désignation: ANTXR1

Sujet:

Synonyms: Voltage-dependent calcium channel subunit alpha-2/delta-2, Voltage-gated calcium channel subunit alpha-2/delta-2, Voltage-dependent calcium channel subunit alpha-2-2, Voltage-dependent calcium channel subunit delta-2, CACNA2D2, KIAA0558

Tissue Specificity: Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta and brain.

Background: Anthrax toxin receptor 1 (ANTXR1 or also known asTEM8) is a protein that in humans is encoded by the ANTXR1 gene. This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.

Poids moléculaire: 80 kDa

ID gène: 84168

UniProt: Q9H6X2