CRH anticorps (AA 185-196)

N° du produit ABIN726800

L’anticorps Lapin Polyclonal anti-CRH a été validé pour WB, ELISA, IHC (p), IF (cc), IF (p) et IHC (fro). Il convient pour détecter CRH dans des échantillons de Humain, Rat et Souris. Il y a 2+ publications disponibles.

Aperçu rapide pour CRH anticorps (AA 185-196) (ABIN726800)

Antigène: CRH (Corticotropin Releasing Hormone (CRH))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRH est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-CRH anticorps

Épitope: AA 185-196

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Pig,Chicken,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CRF

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-CRH (ABIN726800)

Balan, Warnock, Puche, Gondre-Lewis, June, Aurelian: "The GABAA Receptor α2 Subunit Activates a Neuronal TLR4 Signal in the Ventral Tegmental Area that Regulates Alcohol and Nicotine Abuse." dans: Brain sciences, Vol. 8, Issue 4, (2018) (PubMed).

Balan, Warnock, Puche, Gondre-Lewis, Aurelian: "Innately activated TLR4 signal in the nucleus accumbens is sustained by CRF amplification loop and regulates impulsivity." dans: Brain, behavior, and immunity, (2017) (PubMed).

Détails sur CRH

Antigène: CRH (Corticotropin Releasing Hormone (CRH))

Autre désignation: CRF

Sujet:

Synonyms: Corticoliberin, Corticoliberin precursor, Corticotropin releasing factor, Corticotropin releasing hormone, Corticotropin releasing hormone deficiency included, crf, crh, crh deficiency included, corticoliberin preproprotein, CRF_HUMAN, Corticotropin-releasing factor, CRF, CRH, Corticotropin-releasing hormone.

Background: Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010].

ID gène: 1392

UniProt: P06850

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Activity, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Feeding Behaviour