DMC1 anticorps (AA 36-283)

N° du produit ABIN7601468

Cet anticorps anti-DMC1 est un anticorps Lapin Polyclonal détectant DMC1 dans WB, ELISA, IHC et FACS. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour DMC1 anticorps (AA 36-283) (ABIN7601468)

Antigène: DMC1 (DNA Meiotic Recombinase 1 (DMC1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DMC1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Détail du produit anti-DMC1 anticorps

Épitope: AA 36-283

Fonction: Anti-DMC1 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-DMC1 Antibody Picoband® (ABIN7601468). Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human DMC1 recombinant protein (Position: D36-D283).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Cloud, V., Chan, Y.-L., Grubb, J., Budke, B., Bishop, D. K. Rad51 is an accessory factor for Dmc1-mediated joint molecule formation during meiosis. Science 337: 1222-1225, 2012. 2. Habu, T., Taki, T., West, A., Nishimune, Y., Morita, T. The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon-skipped transcript in meiosis. Nucleic Acids Res. 24: 470-477, 1996. 3. He, W.-B., Tu, C.-F., Liu, Q., Meng, L.-L., Yuan, S.-M., Luo, A.-X., He, F.-S., Shen, J., Li, W., Du, J., Zhong, C.-G., Lu, G.-X., Lin, G., Fan, L.-Q., Tan, Y.-Q. DMC1 mutation that causes human non-obstructive azoospermia and premature ovarian insufficiency identified by whole-exome sequencing. J. Med. Genet. 55: 198-204, 2018.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur DMC1

Antigène: DMC1 (DNA Meiotic Recombinase 1 (DMC1))

Autre désignation: DMC1

Sujet:

Synonyms: Aldo-keto reductase family 1 member B10,1.1.1.-,ARL-1,Aldose reductase-like,Aldose reductase-related protein,ARP,hARP,Small intestine reductase,SI reductase,AKR1B10,AKR1B11,

Tissue Specificity: Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.

Background: Meiotic recombination protein DMC1/LIM15 homolog is a protein that in humans is encoded by the DMC1 gene. This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 37 kDa

ID gène: 11144

UniProt: Q14565