Replication Termination Factor 2 (RTF2) (AA 4-306) anticorps

N° du produit ABIN7601620

L’anticorps Lapin Polyclonal anti- a été validé pour ELISA, IP, WB, FACS, ICC et IF. Il convient pour détecter dans des échantillons de Humain.

Aperçu rapide pour Replication Termination Factor 2 (RTF2) (AA 4-306) anticorps (ABIN7601620)

Antigène: Replication Termination Factor 2 (RTF2)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: ELISA, Immunoprecipitation (IP), Western Blotting (WB), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit

Épitope: AA 4-306

Fonction: Anti-RTF2 Antibody Picoband®

Attributs du produit: Anti-RTF2 Antibody Picoband® (ABIN7601620). Tested in ELISA, Flow Cytometry, IP, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human RTF2 recombinant protein (Position: D4-F306). Human RTF2 shares 87.8% and 88.1% amino acid (aa) sequence identity with mouse and rat RTF2, respectively.

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Immunoprecipitation, 0.5-2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Chia, B. S., Li, B., Cui, A., Eisenhaure, T., Raychowdhury, R., Lieb, D., & Hacohen, N. (2020). Loss of the nuclear protein RTF2 enhances influenza virus replication. Journal of Virology, 94(22), 10-1128. 2. Suo, D., Wang, L., Zeng, T., Zhang, H., Li, L., Liu, J., ... & Li, Y. (2020). NRIP3 upregulation confers resistance to chemoradiotherapy in ESCC via RTF2 removal by accelerating ubiquitination and degradation of RTF2. Oncogenesis, 9(8), 75. 3. Kottemann, M. C., Conti, B. A., Lach, F. P., & Smogorzewska, A. (2018). Removal of RTF2 from stalled replisomes promotes maintenance of genome integrity. Molecular cell, 69(1), 24-35.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détail du antigène

Antigène: Replication Termination Factor 2 (RTF2)

Autre désignation: RTF2

Sujet: Replication termination factor 2 is a protein that in humans is encoded by the RTF2 gene. Replication Termination Factor 2, often abbreviated as RTF2, is a protein involved in the regulation and termination of DNA replication processes in eukaryotic cells. It plays a crucial role in ensuring the accurate completion of DNA synthesis during cell division by coordinating the termination of replication forks at specific sites along the DNA strands. RTF2 functions by interacting with other proteins and DNA sequences to facilitate the orderly disassembly of the replication machinery and the prevention of unnecessary re-replication of genomic regions. Its activity is tightly regulated to maintain genomic stability and fidelity, making it a key player in cell cycle control mechanisms. Studies on RTF2 have provided insights into the molecular mechanisms governing DNA replication termination and its implications for cellular function and genome maintenance.

Poids moléculaire: 37 kDa

ID gène: 51507