GRM2 anticorps (AA 439-710)

N° du produit ABIN7601733

Cet anticorps Lapin Polyclonal détecte spécifiquement GRM2 dans ELISA, WB, IHC et FACS. Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour GRM2 anticorps (AA 439-710) (ABIN7601733)

Antigène: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRM2 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Détail du produit anti-GRM2 anticorps

Épitope: AA 439-710

Fonction: Anti-Metabotropic glutamate receptor 2/GRM2 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Metabotropic glutamate receptor 2/GRM2 Antibody (ABIN7601733). Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Metabotropic glutamate receptor 2/GRM2 recombinant protein (Position: N439-A710).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.25 μg/mL, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Flow Cytometry(Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Flor PJ, Lindauer K, Püttner I, Rüegg D, Lukic S, Knöpfel T, Kuhn R (April 1995). "Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2". The European Journal of Neuroscience. 7 (4): 622-9. 2. Kammermeier PJ, Davis MI, Ikeda SR (January 2003). "Specificity of metabotropic glutamate receptor 2 coupling to G proteins". Molecular Pharmacology. 63 (1): 183-91. 3. Jin LE, Wang M, Yang ST, Yang Y, Galvin VC, Lightbourne TC, Ottenheimer D, Zhong Q, Stein J, Raja A, Paspalas CD, Arnsten AF (November 2017). "mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur GRM2

Antigène: GRM2 (Glutamate Receptor, Metabotropic 2 (GRM2))

Autre désignation: GRM2

Sujet:

Synonyms: Metabotropic glutamate receptor 2; mGluR2; GRM2; GPRC1B, MGLUR2

Tissue Specificity: Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain.

Background: Metabotropic glutamate receptor 2  (mGluR2) is a protein that, in humans, is encoded by the GRM2 gene. It is mapped to 3p21.2. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 100 kDa, >200 kDa

ID gène: 2912

UniProt: Q14416

Pathways: cAMP Metabolic Process, Dicarboxylic Acid Transport