alpha 2 Antiplasmin anticorps (AA 461-491)

N° du produit ABIN7601808

Cet anticorps Lapin Polyclonal détecte spécifiquement alpha 2 Antiplasmin dans WB, IHC et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour alpha 2 Antiplasmin anticorps (AA 461-491) (ABIN7601808)

Antigène: alpha 2 Antiplasmin (SERPINF2) (Alpha2 Antiplasmin (SERPINF2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp alpha 2 Antiplasmin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-alpha 2 Antiplasmin anticorps

Épitope: AA 461-491

Fonction: Anti-Alpha 2 Antiplasmin/SERPINF2 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Alpha 2 Antiplasmin/SERPINF2 Antibody Picoband® (ABIN7601808). Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Alpha 2 Antiplasmin/SERPINF2 recombinant protein (Position: K461-K491).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Bangert, K., Johnsen, A. H., Christensen, U., Thorsen, S. Different N-terminal forms of alpha-2-plasmin-inhibitor in human plasma. Biochem. J. 291: 623-625, 1993. 2. Favier, R., Aoki, N., de Moerloose, P. Congenital alpha-2-plasmin inhibitor deficiencies: a review. Brit. J. Haemat. 114: 4-10, 2001. 3. Hirosawa, S., Nakamura, Y., Miura, O., Sumi, Y., Aoki, N. Organization of the human alpha-2-plasmin inhibitor gene. Proc. Nat. Acad. Sci. 85: 6836-6840, 1988. Note: Erratum: Proc. Nat. Acad. Sci. 86: 1612-1613, 1989.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur alpha 2 Antiplasmin

Antigène: alpha 2 Antiplasmin (SERPINF2) (Alpha2 Antiplasmin (SERPINF2))

Autre désignation: SERPINF2

Sujet:

Synonyms: Low affinity immunoglobulin epsilon Fc receptor, BLAST-2, C-type lectin domain family 4 member J, Fc-epsilon-RII, Immunoglobulin E-binding factor, Lymphocyte IgE receptor, CD23, Low affinity immunoglobulin epsilon Fc receptor membrane-bound form, Low affinity immunoglobulin epsilon Fc receptor soluble form, FCER2, CD23A, CLEC4J, FCE2, IGEBF

Tissue Specificity: Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.

Background: Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin. Plasmin is an important enzyme that participates in fibrinolysis and degradation of various other proteins. This protein is encoded by the SERPINF2 gene. This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 65 kDa

ID gène: 5345

UniProt: P08697

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones