HMMR anticorps (AA 5-686)

N° du produit ABIN7601892

Cet anticorps Lapin Polyclonal détecte spécifiquement HMMR dans WB, ELISA, FACS, IF et ICC. Il présente une réactivité envers Humain.

Aperçu rapide pour HMMR anticorps (AA 5-686) (ABIN7601892)

Antigène: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HMMR est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-HMMR anticorps

Épitope: AA 5-686

Fonction: Anti-CD168/HMMR Picoband® Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-/HMMR Picoband® Antibody (ABIN7601892). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human CD168/HMMR recombinant protein (Position: K5-D686).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
1. Pujana, M. A., Han, J.-D. J., Starita, L. M., Stevens, K. N., Tewari, M., Ahn, J. S., Rennert, G., Moreno, V., Kirchhoff, T., Gold, B., Assmann, V., ElShamy, W. M., and 22 others. Network modeling links breast cancer susceptibility and centrosome dysfunction. Nature Genet. 39: 1338-1349, 2007. 2. Savani, R. C., Wang, C., Yang, B. H., Zhang, S. W., Kinsella, M. G., Wight, T. N., Stern, R., Nance, D. M., Turley, E. A. Migration of bovine aortic smooth muscle cells after wounding injury: the role of hyaluronan and RHAMM. J. Clin. Invest. 95: 1158-1168, 1995. 3. Spicer, A. P., Roller, M. L., Camper, S. A., McPherson, J. D., Wasmuth, J. J., Hakim, S., Wang, C., Turley, E. A., McDonald, J. A. The human and mouse receptors for hyaluronan-mediated motility, RHAMM, genes (HMMR) map to human chromosome 5q33.2-qter and mouse chromosome 11. Genomics 30: 115-117, 1995.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur HMMR

Antigène: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Autre désignation: HMMR

Sujet:

Synonyms: Hyaluronan mediated motility receptor, Intracellular hyaluronic acid-binding protein, Receptor for hyaluronan-mediated motility, CD168, HMMR, IHABP, RHAMM

Tissue Specificity: May be up-regulated in bone metastatic breast cancer cells.

Background: Hyaluronan-mediated motility receptor (HMMR), also known as RHAMM (Receptor for Hyaluronan Mediated Motility) is a protein which in humans is encoded by the HMMR gene. It is mapped to 5q34. The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Poids moléculaire: 84 kDa

ID gène: 3161

UniProt: O75330

Pathways: Glycosaminoglycan Metabolic Process