PREX2 anticorps (AA 582-1094)

N° du produit ABIN7602086

Cet anticorps anti-PREX2 est un anticorps Lapin Polyclonal détectant PREX2 dans ELISA et WB. Adapté pour Humain et Souris.

Aperçu rapide pour PREX2 anticorps (AA 582-1094) (ABIN7602086)

Antigène: PREX2 (DEPDC2) (DEP Domain Containing 2 (DEPDC2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PREX2 est non-conjugé

Application: ELISA, Western Blotting (WB)

Détail du produit anti-PREX2 anticorps

Épitope: AA 582-1094

Fonction: Anti-PREX2 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-PREX2 Antibody Picoband® (ABIN7602086). Tested in ELISA, WB applications. This antibody reacts with Human, MouseThe brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PREX2 recombinant protein (Position: D582-Q1094).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Mouse
ELISA, 0.1-0.5 μg/mL, -
1. Berger, M. F., Hodis, E., Heffernan, T. P., Deribe, Y. L., Lawrence, M. S., Protopopov, A., Ivanova, E., Watson, I. R., Nickerson, E., Ghosh, P., Zhang, H., Zeid, R., and 36 others. Melanoma genome sequencing reveals frequent PREX2 mutations. Nature 485: 502-506, 2012. 2. Donald, S., Hill, K., Lecureuil, C., Barnouin, R., Krugmann, S., Coadwell, W. J., Andrews, S. R., Walker, S. A., Hawkins, P. T., Stephens, L. R., Welch, H. C. E. P-Rex2, a new guanine-nucleotide exchange factor for Rac. FEBS Lett. 572: 172-176, 2004. 3. Donald, S., Humby, T., Fyfe, I., Segonds-Pichon, A., Walker, S. A., Andrews, S. R., Coadwell, W. J., Emson, P., Wilkinson, L. S., Welch, H. C. E. P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. Proc. Nat. Acad. Sci. 105: 4483-4488, 2008.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur PREX2

Antigène: PREX2 (DEPDC2) (DEP Domain Containing 2 (DEPDC2))

Autre désignation: PREX2

Sujet:

Synonyms: Neurocan core protein, Chondroitin sulfate proteoglycan 3, NCAN, CSPG3, NEUR,

Tissue Specificity: Brain.

Background: Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 is a protein that in humans is encoded by the PREX2 gene. The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers.

Poids moléculaire: 183 kDa

ID gène: 80243

UniProt: Q70Z35