Renin anticorps (AA 80-370)

N° du produit ABIN7602514

L’anticorps Lapin Polyclonal anti-Renin a été validé pour WB, IHC et ELISA. Il convient pour détecter Renin dans des échantillons de Humain, Rat et Souris.

Aperçu rapide pour Renin anticorps (AA 80-370) (ABIN7602514)

Antigène: Renin (REN)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Renin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-Renin anticorps

Épitope: AA 80-370

Fonction: Anti-Renin/REN Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Renin/REN Antibody Picoband® (ABIN7602514). Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Renin/REN recombinant protein (Position: N80-D370).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Abel, K. J., Gross, K. W. Close physical linkage of the murine Ren-1 and Ren-2 loci. Nucleic Acids Res. 16: 2111-2126, 1988. 2. Caron, K. M. I., James, L. R., Kim, H.-S., Knowles, J., Uhlir, R., Mao, L., Hagaman, J. R., Cascio, W., Rockman, H., Smithies, O. Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene. Proc. Nat. Acad. Sci. 101: 3106-3111, 2004. 3. Chirgwin, J. M., Schaefer, I. M., Diaz, J. A., Lalley, P. A. Mouse kidney renin gene is on chromosome one. Somat. Cell Molec. Genet. 10: 633-637, 1984.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur Renin

Antigène: Renin (REN)

Autre désignation: REN

Sujet:

Synonyms: p-selectin glycoprotein ligand, Selplg, Psgl1

Tissue Specificity: Highly expressed in blood, bone marrow, brain, adipose tissue, spleen, and thymus. Also expressed in heart, kidney, liver, muscle, ovary, and stomach.

Background: This gene encodes renin, an aspartic protease that is secreted by the kidneys. Renin is a part of the renin-angiotensin-aldosterone system involved in regulation of blood pressure, and electrolyte balance. This enzyme catalyzes the first step in the activation pathway of angiotensinogen by cleaving angiotensinogen to form angiotensin I, which is then converted to angiotensin II by angiotensin I converting enzyme. This cascade can result in aldosterone release, narrowing of blood vessels, and increase in blood pressure as angiotension II is a vasoconstrictive peptide. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause hyperuricemic nephropathy familial juvenile 2, familial hyperproreninemia, and renal tubular dysgenesis.

Poids moléculaire: 55 kDa

ID gène: 5972

UniProt: P00797

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour