ALDOB anticorps (AA 85-364)

N° du produit ABIN7602563

Cet anticorps anti-ALDOB est un anticorps Lapin Polyclonal détectant ALDOB dans WB, ELISA, IHC, ICC, IF et FACS. Adapté pour Humain, Rat, Souris et Singe.

Aperçu rapide pour ALDOB anticorps (AA 85-364) (ABIN7602563)

Antigène: ALDOB (Aldolase B, Fructose-Bisphosphate (ALDOB))

Reactivité: Humain, Rat, Souris, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALDOB est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS)

Détail du produit anti-ALDOB anticorps

Épitope: AA 85-364

Fonction: Anti-Aldolase/ALDOB Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Aldolase/ALDOB Antibody Picoband® (ABIN7602563). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Aldolase/ALDOB recombinant protein (Position: Y85-Y364).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.25 μg/mL, Human, Mouse, Monkey, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Dalby AR, Tolan DR, Littlechild JA (November 2001). "The structure of human liver fructose-1,6-bisphosphate aldolase". Acta Crystallogr. D. 57 (Pt 11): 1526-33. 2. Henry I, Gallano P, Besmond C, Weil D, Mattei MG, Turleau C, Boué J, Kahn A, Junien C (July 1985). "The structural gene for aldolase B (ALDB) maps to 9q13----32". Ann. Hum. Genet. 49 (Pt 3): 173-80. 3. Sygusch J, Beaudry D, Allaire M (November 1987). "Molecular architecture of rabbit skeletal muscle aldolase at 2.7-A resolution". Proc. Natl. Acad. Sci. U.S.A. 84 (22): 7846-50.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur ALDOB

Antigène: ALDOB (Aldolase B, Fructose-Bisphosphate (ALDOB))

Autre désignation: ALDOB

Sujet:

Synonyms: Fructose-bisphosphate aldolase B, Liver-type aldolase, ALDOB, ALDB

Tissue Specificity: Pancreas-specific (at protein level). Loss of expression is seen in ductal type pancreas cancers.

Background: Aldolase B also known as fructose-bisphosphate aldolase B or liver-type aldolase is one of three isoenzymes (A, B, and C) of the class I fructose 1,6-bisphosphate aldolase enzyme (EC 4.1.2.13), and plays a key role in both glycolysis and gluconeogenesis. It is mapped to 9q31.1. Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5 % of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.

Poids moléculaire: 39 kDa

ID gène: 229

UniProt: P05062