NECAB3 anticorps (AA 97-339)

N° du produit ABIN7602707

Cet anticorps anti-NECAB3 est un anticorps Lapin Polyclonal détectant NECAB3 dans WB, ELISA et FACS. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour NECAB3 anticorps (AA 97-339) (ABIN7602707)

Antigène: NECAB3 (N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NECAB3 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-NECAB3 anticorps

Épitope: AA 97-339

Fonction: Anti-NECAB3 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-NECAB3 Antibody Picoband® (ABIN7602707). Tested in ELISA, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human NECAB3 recombinant protein (Position: D97-D339).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. protein metabolism by XB51, a novel X11L-binding protein. J. Biol. Chem. 275: 23134-23138, 2000. 2. Sugita, S., Ho, A., Sudhof, T. C. NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. Neuroscience 112: 51-63, 2002. 3. Sumioka, A., Imoto, S., Martins, R. N., Kirino, Y., Suzuki, T. XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms. Biochem. J. 374: 261-268, 2003.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur NECAB3

Antigène: NECAB3 (N-Terminal EF-Hand Calcium Binding Protein 3 (NECAB3))

Autre désignation: NECAB3

Sujet:

Synonyms: Interleukin-17B, IL-17B, Cytokine CX1, Cytokine-like protein ZCYTO7, Neuronal interleukin-17-related factor, Il17b, Nirf, Zcyto7

Tissue Specificity: Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.

Background: N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene. The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 44 kDa

ID gène: 63941

UniProt: Q96P71