MC4R anticorps (C-Term)

N° du produit ABIN7602763

L’anticorps Lapin Polyclonal anti-MC4R a été validé pour WB, IHC, IF, ICC et FACS. Il convient pour détecter MC4R dans des échantillons de Humain, Rat et Souris.

Aperçu rapide pour MC4R anticorps (C-Term) (ABIN7602763)

Antigène: MC4R (Melanocortin 4 Receptor (MC4R))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MC4R est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Détail du produit anti-MC4R anticorps

Épitope: C-Term

Fonction: Anti-MC4-R/MC4R Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-MC4-R/MC4R Antibody (ABIN7602763). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human MC4-R/MC4R, which shares 88.5% and 80.8% amino acid (aa) sequence identity with mouse and rat MC4-R/MC4R, respectively.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
1. Hardy, R., Wills, A. K., Wong, A., Elks, C. E., Wareham, N. J., Loos, R. J. F., Kuh, D., Ong, K. K. Life course variations in the associations between FTO and MC4R gene variants and body size. Hum. Molec. Genet. 19: 545-552, 2010. 2. Hebebrand, J., Geller, F., Dempfle, A., Heinzel-Gutenbrunner, M., Raab, M., Gerber, G., Wermter, A.-K., Horro, F. F., Blundell, J., Schafer, H., Remschmidt, H., Herpertz, S., Hinney, A. Binge-eating episodes are not characteristic of carriers of melanocortin-4 receptor gene mutations. Molec. Psychiat. 9: 796-800, 2004. 3. Heid, I. M., Vollmert, C., Hinney, A., Doring, A., Geller, F., Lowel, H., Wichmann, H.-E., Illig, T., Hebebrand, J., Kronenberg, F., the KORA group. Association of the 1031 MC4R allele with decreased body mass in 7937 participants of two population based surveys. J. Med. Genet. 42: e21, 2005. Note: Electronic Article.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur MC4R

Antigène: MC4R (Melanocortin 4 Receptor (MC4R))

Autre désignation: MC4R

Sujet:

Synonyms: Melanocortin receptor 4, MC4-R, MC4R

Tissue Specificity: Brain, placental, and gut tissues.

Background: Melanocortin receptor 4 is a protein that in humans is encoded by the MC4R gene. This gene is mapped to 18q21.32. The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity.

Poids moléculaire: 37 kDa

ID gène: 4160

UniProt: P32245

Pathways: Hormone Transport, cAMP Metabolic Process, Feeding Behaviour