DDC anticorps (C-Term)

N° du produit ABIN7602877

L’anticorps Lapin Polyclonal anti-DDC a été validé pour WB et FACS. Il convient pour détecter DDC dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour DDC anticorps (C-Term) (ABIN7602877)

Antigène: DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDC est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit anti-DDC anticorps

Épitope: C-Term

Fonction: Anti-DOPA decarboxylase/DDC Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-DOPA decarboxylase/DDC Antibody Picoband® (ABIN7602877). Tested in WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human DOPA decarboxylase/DDC, which shares 76% amino acid (aa) sequence identity with both mouse and rat DOPA decarboxylase/DDC.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
1. Bonnin, A., Goeden, N., Chen, K., Wilson, M. L., King, J., Shih, J. C., Blakely, R. D., Deneris, E. S., Levitt, P. A transient placental source of serotonin for the fetal forebrain. Nature 472: 347-350, 2011. 2. Brun, L., Ngu, L. H., Keng, W. T., Ch'ng, G. S., Choy, Y. S., Hwu, W. L., Lee, W. T., Willemsen, M. A. A. P., Verbeek, M. M., Wassenberg, T., Regal, L., Orcesi, S., and 13 others. Clinical and biochemical features of aromatic L-amino acid decarboxylase deficiency. Neurology 75: 64-71, 2010. Note: Erratum: Neurology 75: 576 only, 2010. 3. Bruneau, G., Gross, M.-S., Krieger, M., Bernheim, A., Thibault, J., Nguyen, V. C. Preparation of a human DOPA decarboxylase cDNA probe by PCR and its assignment to chromosome 7. Ann. Genet. 33: 208-213, 1990.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur DDC

Antigène: DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

Autre désignation: DDC

Sujet:

Synonyms: DDC, AADC, Aromatic-L-amino-acid decarboxylase, AADC, EC 4.1.1.28, DOPA decarboxylase, DDC

Background: The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Poids moléculaire: 50 kDa

ID gène: 1644

UniProt: P20711

Pathways: Dopaminergic Neurogenesis