GZMK anticorps (Middle Region)

N° du produit ABIN7603055

Cet anticorps anti-GZMK est un anticorps Lapin Polyclonal détectant GZMK dans IHC. Adapté pour Humain.

Aperçu rapide pour GZMK anticorps (Middle Region) (ABIN7603055)

Antigène: GZMK (Granzyme K (Granzyme 3, Tryptase II) (GZMK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GZMK est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-GZMK anticorps

Épitope: Middle Region

Fonction: Anti-Granzyme K/GZMK Antibody

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Granzyme K/GZMK Antibody Picoband® (ABIN7603055). Tested in IHC applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human Granzyme K/GZMK, which shares 71.4% and 73.9% amino acid (aa) sequence identity with mouse and rat GZMK, respectively.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
1. Baker, E., Sayers, T. J., Sutherland, G. R., Smyth, M. J. The genes encoding NK cell granule serine proteases, human tryptase-2 (TRYP2) and human granzyme A (HFSP), both map to chromosome 5q11-q12 and define a new locus for cytotoxic lymphocyte granule tryptases. Immunogenetics 40: 235-237, 1994. 2. Przetak, M. M., Yoast, S., Schmidt, B. F. Cloning of cDNA for human granzyme 3. FEBS Lett. 364: 268-271, 1995. 3. Sayers, T. J., Lloyd, A. R., McVicar, D. W., O'Connor, M. D., Kelly, J. M., Carter, C. R. D., Wiltrout, T. A., Wiltrout, R. H., Smyth, M. J. Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3. J. Leuko. Biol. 59: 763-768, 1996.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur GZMK

Antigène: GZMK (Granzyme K (Granzyme 3, Tryptase II) (GZMK))

Autre désignation: GZMK

Sujet:

Synonyms: ELAV-like protein 2, ELAV-like neuronal protein 1, Hu-antigen B, HuB, Nervous system-specific RNA-binding protein Hel-N1, ELAVL2, HUB

Tissue Specificity: Brain, neural-specific.

Background: Granzyme K is a protein that in humans is encoded by the GZMK gene. This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes

Poids moléculaire: 41 kDa

ID gène: 3003

UniProt: P49863