FUBP1 anticorps (N-Term)

N° du produit ABIN7603217

Cet anticorps anti-FUBP1 est un anticorps Lapin Polyclonal détectant FUBP1 dans WB, IHC, IF et ICC. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour FUBP1 anticorps (N-Term) (ABIN7603217)

Antigène: FUBP1 (Far Upstream Element (FUSE) Binding Protein 1 (FUBP1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FUBP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-FUBP1 anticorps

Épitope: N-Term

Fonction: Anti-FUBP1 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-FUBP1 Antibody Picoband® (ABIN7603217). Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human FUBP1.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry, 2-5 μg/mL, Human, Mouse
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
1. Bettegowda, C., Agrawal, N., Jiao, Y., Sausen, M., Wood, L. D., Hruban, R. H., Rodriguez, F. J., Cahill, D. P., McLendon, R., Riggins, G., Velculescu, V. E., Oba-Shinjo, S. M., Marie, S. K. N., Vogelstein, B., Bigner, D., Yan, H., Papadopoulos, N., Kinzler, K. W. Mutations in CIC and FUBP1 contribute to human oligodendroglioma. Science 333: 1453-1455, 2011. 2. Duncan, R., Bazar, L., Michelotti, G., Tomonaga, T., Krutzsch, H., Avigan, M., Levens, D. A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif. Genes Dev. 8: 465-480, 1994. 3. Liu, J., Akoulitchev, S., Weber, A., Ge, H., Chuikov, S., Libutti, D., Wang, X. W., Conaway, J. W., Harris, C. C., Conaway, R. C., Reinberg, D., Levens, D. Defective interplay of activators and repressors with TFIIH in xeroderma pigmentosum. Cell 104: 353-363, 2001.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur FUBP1

Antigène: FUBP1 (Far Upstream Element (FUSE) Binding Protein 1 (FUBP1))

Autre désignation: FUBP1

Sujet:

Synonyms: FUBP1, Far upstream element-binding protein 1, FBP, FUSE-binding protein 1, DNA helicase V, hDH V

Background: The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 67 kDa

ID gène: 8880